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    sPLA2 secretory Phospholipase A2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sPLA2provided by FlyBase
    Official Full Name
    secretory Phospholipase A2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033170
    Locus tag
    Dmel_CG11124
    See related
    AllianceGenome:FB:FBgn0033170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11124; CG14507; Dmel\CG11124; secretory phospholipase A[[2]]; sPLA[[2]]
    Summary
    Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonate secretion and phospholipid metabolic process. Is expressed in organism. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sPLA2 in Genome Data Viewer
    Location:
    43C1-43C1; 2-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7442864..7443827)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3330369..3331332)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sine oculis Neighboring gene long non-coding RNA:CR44203 Neighboring gene long non-coding RNA:CR44204 Neighboring gene uncharacterized protein Neighboring gene kappaB-Ras Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid 2-hydroxylase Neighboring gene long non-coding RNA:CR45320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a gene encoding the Drosophila melanogaster phospholipase A2. Ryu Y, et al. Biochim Biophys Acta, 2003 Aug 25. PMID 12932833
    2. Disruption of INOS, a Gene Encoding myo-Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster. Jackson NAM, et al. G3 (Bethesda), 2018 Aug 30. PMID 29991509, Free PMC Article
    3. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    4. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
    5. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secretory phospholipase A2
    Names
    CG11124-PA
    CG11124-PB
    CG11124-PC
    sPLA2-PA
    sPLA2-PB
    sPLA2-PC
    secreted phospholipase A2
    NP_001014501.1
    NP_610277.1
    NP_724556.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7442864..7443827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014501.3 → NP_001014501.1  secretory phospholipase A2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWR6, Q6XPX3
      Conserved Domains (1) summary
      cd04704
      Location:43 → 139
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...

    2. NM_136433.3 → NP_610277.1  secretory phospholipase A2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZB2
      Related
      FBpp0099485
      Conserved Domains (1) summary
      cl05417
      Location:43 → 101
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    3. NM_165523.3 → NP_724556.1  secretory phospholipase A2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWR6, Q6XPX3
      Related
      FBpp0099484
      Conserved Domains (1) summary
      cd04704
      Location:43 → 139
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWR6 Q6AWR6
    Q6XPX3 Q6XPX3
    Q8SZB2 Q8SZB2

    Gene LinkOut

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