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    Ctu1 Cytosolic thiouridylase subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctu1provided by FlyBase
    Official Full Name
    Cytosolic thiouridylase subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033375
    Locus tag
    Dmel_CG8078
    See related
    AllianceGenome:FB:FBgn0033375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.76; CG8078; Dmel\CG8078
    Summary
    Predicted to enable sulfurtransferase activity and tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Is expressed in embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctu1 in Genome Data Viewer
    Location:
    45A3-45A3; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9096931..9098525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4984436..4986030, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Van Gogh

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    2. A computational search for box C/D snoRNA genes in the Drosophila melanogaster genome. Accardo MC, et al. Bioinformatics, 2004 Dec 12. PMID 15247100
    3. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Jiang N, et al. Mol Cell Biol, 2009 Jul. PMID 19380483, Free PMC Article
    4. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Murray MJ, et al. Dev Biol, 2012 Dec 1. PMID 23000359
    5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic tRNA wobble base thiouridylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic thiouridylase subunit 1
    Names
    CG8078-PA
    Ctu1-PA
    NP_610451.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9096931..9098525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136607.2 → NP_610451.1  cytosolic thiouridylase subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JWW5
      Related
      FBpp0087712
      Conserved Domains (3) summary
      TIGR00269
      Location:203 → 304
      TIGR00269; TIGR00269 family protein
      COG0037
      Location:28 → 311
      TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
      cd01993
      Location:52 → 239
      Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWW5.1 Q7JWW5

    Gene LinkOut

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    Other Literature Sources
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