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    Ir48c Ionotropic receptor 48c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir48cprovided by FlyBase
    Official Full Name
    Ionotropic receptor 48cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033651
    Locus tag
    Dmel_CG12444
    See related
    AllianceGenome:FB:FBgn0033651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    48c; CG12444; DmelIR48c; Dmel\CG12444; IR48c; Tango3; TANGO3
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Involved in Golgi organization and protein secretion. Located in endoplasmic reticulum. Is expressed in larval gustatory receptor neuron of the dorsal pharyngeal sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir48c in Genome Data Viewer
    Location:
    48C3-48C3; 2-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11787808..11789493, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7675313..7676998, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thisbe Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sine oculis-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive local adaptation within the chemosensory system following Drosophila melanogaster's global expansion. Arguello JR, et al. Nat Commun, 2016 Jun 13. PMID 27292132, Free PMC Article
    2. Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Markstein M, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11752406, Free PMC Article
    3. Candidate ionotropic taste receptors in the Drosophila larva. Stewart S, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25825777, Free PMC Article
    4. FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. Kadam S, et al. Development, 2009 Mar. PMID 19158183, Free PMC Article
    5. The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors. Koh TW, et al. Neuron, 2014 Aug 20. PMID 25123314, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 48c
    Names
    CG12444-PB
    Ir48c-PB
    transport and golgi organization 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11787808..11789493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136856.1 → NP_610700.1  ionotropic receptor 48c [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8P2
      Related
      FBpp0087171, FBtr0088065
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8P2 A1Z8P2

    Gene LinkOut

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