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    GstE14 Glutathione S transferase E14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36467, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstE14provided by FlyBase
    Official Full Name
    Glutathione S transferase E14provided by FlyBase
    Primary source
    FLYBASE:FBgn0033817
    Locus tag
    Dmel_CG4688
    See related
    AllianceGenome:FB:FBgn0033817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4688; Dmel\CG4688; DmGSTE14; DmNobo; gste14; GSTE14; nobo; Nobo
    Summary
    Enables glutathione transferase activity and steroid delta-isomerase activity. Involved in cholesterol homeostasis; ecdysteroid biosynthetic process; and glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in amnioserosa; follicle cell; ovary; prothoracic gland; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE14 in Genome Data Viewer
    Location:
    49F12-49F12; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13239729..13241013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9127234..9128518)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45278 Neighboring gene Muscle protein 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators. Ebihara K, et al. Biomolecules, 2023 Mar 2. PMID 36979396, Free PMC Article
    2. A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors. Fujikawa Y, et al. Chem Commun (Camb), 2015 Jul 21. PMID 26090533
    3. Glutathione Transferases as Efficient Ketosteroid Isomerases. Mannervik B, et al. Front Mol Biosci, 2021. PMID 34881290, Free PMC Article
    4. Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis. Škerlová J, et al. FEBS Lett, 2020 Apr. PMID 31845319
    5. Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo. Koiwai K, et al. J Pestic Sci, 2021 Feb 20. PMID 33746549, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis.
      Title: Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis.
    2. An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo.
      Title: An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo.
    3. the PG-specific nobo knock-down larvae displayed an arrested phenotype and reduced 20-hydroxyecdysone (20E) titres. Importantly, both embryonic and larval phenotypes were rescued by the administration of 20E or cholesterol.
      Title: A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila.
    4. identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development
      Title: Pri peptides are mediators of ecdysone for the temporal control of development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E14
    Names
    CG4688-PA
    GstE14-PA
    Noppera-bo
    NP_610855.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13239729..13241013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137011.3 → NP_610855.1  glutathione S transferase E14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JYX0
      Related
      FBpp0086857
      Conserved Domains (3) summary
      cd03177
      Location:94 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 200
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:6 → 79
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYX0.1 Q7JYX0

    Gene LinkOut

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