arr arrow [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: arrprovided by FlyBase
Official Full Name: arrowprovided by FlyBase
Primary source: FLYBASE:FBgn0000119
Locus tag: Dmel_CG5912
See related: AllianceGenome:FB:FBgn0000119
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Arr; Arw; BEST:CK00539; CG5912; CK00539; CT15575; Dm Arr; Dmel\CG5912; Irp6; l(2)k08131; LRP; LRP/Arr; LRP5/6; LRP6
Summary: Enables Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; long-term memory; and regionalization. Located in plasma membrane. Part of Wnt signalosome. Colocalizes with early endosome and late endosome. Is expressed in several structures, including embryonic dorsal epidermis; embryonic ventral epidermis; foregut primordium; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in several diseases, including bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; polycystic liver disease (multiple); and tooth agenesis. Orthologous to human LRP5 (LDL receptor related protein 5) and LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50A9-50A11; 2-68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13453640..13483229, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9341145..9370734, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A conserved role for arrow in posterior axis patterning across Arthropoda.
Title: A conserved role for arrow in posterior axis patterning across Arthropoda.
Study find that Arr is required for canonical pathway activation only if Dsh is not membrane localized.
Title: Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.
Dishevelled signals through LRP5/6 in human cells and Drosophila embryos.
Title: Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization.
Arrow functions as an endocytic receptor for Wingless in the Drosophila wing
Title: Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.
Frizzled2 achieves ligand capture and internalization, whereas Arrow, and perhaps downstream signalling, are essential for lysosomal targeting.
Title: Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables coreceptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of Wnt-Frizzled-LRP5/6 complex	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arrow

Names: CG5912-PA; Dm arrow; LDL-related protein 6; LDLR-like; LRP5/6/Arrow; arr-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13453640..13483229 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079998.4 → NP_524737.2 arrow [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524737.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9D7, Q9NHE9

Related

FBpp0086821

Conserved Domains (7) summary

smart00192
Location:1399 → 1433

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:776 → 818

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1319 → 1362

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:172 → 237

NHL; NHL repeat [structural motif]

pfam00058
Location:534 → 573

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:973 → 1010

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl18310
Location:168 → 503

NHL; NHL repeat unit of beta-propeller proteins