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    qsm quasimodo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47065, updated on 17-Dec-2024

    Summary

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    Official Symbol
    qsmprovided by FlyBase
    Official Full Name
    quasimodoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028622
    Locus tag
    Dmel_CG13432
    See related
    AllianceGenome:FB:FBgn0028622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13432; CG13433; Dmel\CG13432; EP2356; EP2587; l(2)05510; L(2)05510; l(2)k009920; lethal (2) 05510; Qsm; QSM
    Summary
    Involved in locomotor rhythm. Is expressed in several structures, including adult pacemaker neurons; cuboidal/columnar epithelium; gut section; imaginal disc; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qsm in Genome Data Viewer
    Location:
    57A5-57A6; 2-91 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20563034..20583591, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16450539..16471096, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lateral muscles scarcer Neighboring gene Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Neighboring gene antisense RNA:CR44653 Neighboring gene uncharacterized protein Neighboring gene mir-310 stem loop Neighboring gene mir-311 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. Sarkar M, et al. J Biol Chem, 2006 May 5. PMID 16522637
    2. Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration. Levine B, et al. Dev Biol, 2007 May 1. PMID 17383627
    3. Mechano-chemical enforcement of tendon apical ECM into nano-filaments during Drosophila flight muscle development. Chu WC, et al. Curr Biol, 2021 Apr 12. PMID 33545042
    4. The opposing chloride cotransporters KCC and NKCC control locomotor activity in constant light and during long days. Eick AK, et al. Curr Biol, 2022 Mar 28. PMID 35303416
    5. Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them. Maruko A, et al. iScience, 2023 Nov 17. PMID 37915609, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Qsm affects both daily and acute light effects in large ventral lateral neurons.
      Title: Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quasimodo
    Names
    CG13432-PA
    CG13432-PB
    lethal (2) 05510
    qsm-PA
    qsm-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20563034..20583591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299708.1 → NP_001286637.1  quasimodo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3W4
      Conserved Domains (2) summary
      smart00241
      Location:30 → 298
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:200 → 300
      Zona_pellucida; Zona pellucida-like domain

    2. NM_143792.3 → NP_652049.1  quasimodo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3W4
      Related
      FBpp0085570
      Conserved Domains (2) summary
      smart00241
      Location:30 → 298
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:200 → 300
      Zona_pellucida; Zona pellucida-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3W4 Q7K3W4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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