Gpdh2 Glycerol-3-phosphate dehydrogenase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gpdh2provided by FlyBase
Official Full Name: Glycerol-3-phosphate dehydrogenase 2provided by FlyBase
Primary source: FLYBASE:FBgn0034825
Locus tag: Dmel_CG3215
See related: AllianceGenome:FB:FBgn0034825
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3215; Dmel\CG3215; gpdh-2; GPDH-2
Summary: Predicted to enable glycerol-3-phosphate dehydrogenase (NAD+) activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23128604..23130189, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19016127..19017712, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_611760.2

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The following sections contain reference sequences that belong to a specific genome build. Explain