Girdin girdin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Girdinprovided by FlyBase
Official Full Name: girdinprovided by FlyBase
Primary source: FLYBASE:FBgn0283724
Locus tag: Dmel_CG12734
See related: AllianceGenome:FB:FBgn0283724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12734; Dmel\CG12734; girdin; mecA
Summary: Predicted to enable dynein light intermediate chain binding activity and microtubule binding activity. Involved in several processes, including dendrite morphogenesis; epithelial cell-cell adhesion; and positive regulation of cell size. Located in adherens junction; cytoplasm; and sensory dendrite. Is expressed in several structures, including embryonic/larval midgut; germline cell; larval central nervous system; scolopidial cilium; and ventral midline of embryo. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to several human genes including CCDC88A (coiled-coil domain containing 88A) and CCDC88C (coiled-coil domain containing 88C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 63B9-63B10; 3-6 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3178930..3185287)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3178930..3185287)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors observed cell dissemination from GIRDIN knockdown cysts and tumorspheres, thereby showing that GIRDIN supports the cohesion of multicellular epithelial structures.
Title: Girdin is a component of the lateral polarity protein network restricting cell dissemination.
Girdin functions temporarily within the sensory organ and that this function is essential for the formation of the sensory dendrites via actin structures
Title: Drosophila Hook-Related Protein (Girdin) Is Essential for Sensory Dendrite Formation.
Studies indicate that knockdown of dGirdin in the Drosophila wing imaginal disc cells resulted in reduction of cell size and this was enhanced by half reduction of the Akt gene dose.
Title: dGirdin a new player of Akt /PKB signaling in Drosophila Melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in spot adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: girdin

Names: CG12734-PA; CG12734-PB; CG12734-PC; CG12734-PD; CG12734-PE; Girdin-PA; Girdin-PB; Girdin-PC; Girdin-PD; Girdin-PE; dGirdin; mechanosensory A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

3178930..3185287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139523.3 → NP_647780.1 girdin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647780.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VZT7

Related

FBpp0072899

Conserved Domains (2) summary

TIGR02168
Location:315 → 1112

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl00143
Location:884 → 1006

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001274429.1 → NP_001261358.1 girdin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261358.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDY5

Conserved Domains (2) summary

TIGR02168
Location:315 → 1112

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl00143
Location:884 → 1006

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001274430.1 → NP_001261359.1 girdin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261359.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEG0

Conserved Domains (1) summary

TIGR02168
Location:315 → 1112

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_206262.3 → NP_995984.1 girdin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995984.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SX64

Conserved Domains (1) summary

TIGR02168
Location:315 → 1112

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001274431.1 → NP_001261360.1 girdin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261360.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE55

Conserved Domains (2) summary

TIGR02168
Location:315 → 1112

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl00143
Location:884 → 1006

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...