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    NijB Ninjurin B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NijBprovided by FlyBase
    Official Full Name
    Ninjurin Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036822
    Locus tag
    Dmel_CG11637
    See related
    AllianceGenome:FB:FBgn0036822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11637; Dmel\CG11637; nijB; NINJ-B
    Summary
    Involved in cytolysis. Predicted to be located in membrane. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NijB in Genome Data Viewer
    Location:
    75E4-75E4; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18892383..18893278)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18885483..18886378)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene UDP-glucose-glycoprotein glucosyltransferase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NINJ1 mediates plasma membrane rupture during lytic cell death. Kayagaki N, et al. Nature, 2021 Mar. PMID 33472215
    2. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Zhang S, et al. Genes Dev, 2006 Jul 15. PMID 16815999, Free PMC Article
    3. Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila. Zhai Z, et al. PLoS Genet, 2012. PMID 22438831, Free PMC Article
    4. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
    5. Single-cell RNA sequencing identifies novel cell types in Drosophila blood. Fu Y, et al. J Genet Genomics, 2020 Apr 20. PMID 32487456, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ninjurin B
    Names
    CG11637-PA
    NijB-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18892383..18893278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140811.2 → NP_649068.1  ninjurin B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V5W5, Q9VVT9
      Related
      FBpp0074832
      Conserved Domains (1) summary
      pfam04923
      Location:75 → 172
      Ninjurin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVT9.1 Q9VVT9

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