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    Invadolysin invadolysin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Invadolysinprovided by FlyBase
    Official Full Name
    invadolysinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086359
    Locus tag
    Dmel_CG3953
    See related
    AllianceGenome:FB:FBgn0086359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3953; Dmel\CG3953; DmIX-14; inv; invadolysin; IX-14; l(3)IX-14; l(3)SG34
    Summary
    Enables peptidase activity. Involved in several processes, including microtubule cytoskeleton organization; mitotic chromosome condensation; and positive regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm; and ganglia. Orthologous to human LMLN (leishmanolysin like peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Invadolysin in Genome Data Viewer
    Location:
    85F14-85F15; 3-49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10144668..10159134)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5970390..5984856)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twins Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bestrophin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Cobbe N, et al. J Cell Sci, 2009 Sep 15. PMID 19706689, Free PMC Article
    2. A role for the metalloprotease invadolysin in insulin signaling and adipogenesis. Chang CW, et al. Biol Chem, 2017 Mar. PMID 27622830
    3. Analysis of an enhancer trap expressed in regenerating Drosophila imaginal discs. Addison WR, et al. Genome, 1995 Aug. PMID 7672606
    4. Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila. Di Cara F, et al. J Cell Sci, 2013 Oct 15. PMID 23943867, Free PMC Article
    5. Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Rao SG, et al. Nucleic Acids Res, 2015 Apr 20. PMID 25779050, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 10152030-10152240 mobile_element_type = transposon:INE-1{}2386

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    invadolysin
    Names
    CG3953-PA
    Invadolysin-PA
    lethal (3) IX-14
    NP_652072.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10144668..10159134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143815.4 → NP_652072.1  invadolysin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NH00, Q9VH19
      Related
      FBpp0081659
      Conserved Domains (1) summary
      cl19482
      Location:93 → 628
      Peptidase_M8; Leishmanolysin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH19.2 Q9VH19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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