Gyc88E Guanylyl cyclase at 88E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gyc88Eprovided by FlyBase
Official Full Name: Guanylyl cyclase at 88Eprovided by FlyBase
Primary source: FLYBASE:FBgn0038295
Locus tag: Dmel_CG4154
See related: AllianceGenome:FB:FBgn0038295
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4154; Dmel\CG4154; GYC; Gyc-88E
Summary: Enables several functions, including carbon monoxide binding activity; guanylate cyclase activity; and protein dimerization activity. Involved in nitric oxide-cGMP-mediated signaling; response to hypoxia; and response to reactive oxygen species. Part of guanylate cyclase complex, soluble. Is expressed in several structures, including brain; external sensory organ; larval ventral nerve cord; and peripheral nervous system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88E2-88E2; 3-56 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15150375..15191242)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10976097..11016964)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

biochemical properties of Gyc-88E are unique for guanylate cyclases and suggest a possible function as an oxygen sensor
Title: Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila.
Mutants of NO-dependent cyclase show a specifically-marked behaviour phenotype, but on the other hand they are associated with moderate biochemical defects.
Title: Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling.
Gyc-88E and Gyc-89Db are co-expressed in a subset of sensory neurons where they would be ideally situated to act as oxygen sensors
Title: Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbon monoxide binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric oxide binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
part_of guanylate cyclase complex, soluble	IC Inferred by Curator more info	PubMed
part_of guanylate cyclase complex, soluble	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylyl cyclase at 88E

Names: CG4154-PD; CG4154-PE; CG4154-PF; Gyc88E-PD; Gyc88E-PE; Gyc88E-PF

NP_001036711.1

EC 4.6.-.-

EC 4.6.1.2

NP_001247115.1

EC 4.6.-.-

EC 4.6.1.2

NP_731974.4

EC 4.6.-.-

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15150375..15191242

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001043246.4 → NP_001036711.1 guanylyl cyclase at 88E, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036711.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2RVE6, Q0KI72, Q6U839, Q6U840, Q8INF0, Q9VFC5

Conserved Domains (4) summary

smart00044
Location:383 → 571

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam07700
Location:2 → 164

HNOB; Haem-NO-binding

pfam07701
Location:201 → 404

HNOBA; Heme NO binding associated

cl28033
Location:794 → 955

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_001260186.2 → NP_001247115.1 guanylyl cyclase at 88E, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247115.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2RVE6, Q0KI72, Q6U839, Q6U840, Q8INF0, Q9VFC5

Conserved Domains (4) summary

smart00044
Location:383 → 571

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam07700
Location:2 → 164

HNOB; Haem-NO-binding

pfam07701
Location:201 → 404

HNOBA; Heme NO binding associated

cl28033
Location:794 → 955

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_169616.4 → NP_731974.4 guanylyl cyclase at 88E, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731974.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8INF0

Conserved Domains (4) summary

smart00044
Location:383 → 571

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:417 → 593

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:2 → 164

HNOB; Haem-NO-binding

pfam07701
Location:201 → 404

HNOBA; Heme NO binding associated