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    naz nazgul [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nazprovided by FlyBase
    Official Full Name
    nazgulprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286852
    Locus tag
    Dmel_CG31235
    See related
    AllianceGenome:FB:FBgn0286852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14311; CG31235; CG7117; Dmel\CG31235; Naz
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain; ganglia; and glial cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See naz in Genome Data Viewer
    Location:
    91A2-91A2; 3-63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18316075..18328942, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14141797..14154664, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein Kinase D Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Ryglewski S, et al. Front Syst Neurosci, 2017. PMID 29021745, Free PMC Article
    2. Expression of a set of glial cell-specific markers in the Drosophila embryonic central nervous system. Ahn HJ, et al. BMB Rep, 2014 Jun. PMID 24286328, Free PMC Article
    3. Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion. Stacey SM, et al. J Neurosci, 2010 Oct 27. PMID 20980602, Free PMC Article
    4. Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki. Losada-Perez M, et al. J Cell Biol, 2016 Aug 29. PMID 27551055, Free PMC Article
    5. Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch. Peco E, et al. Development, 2016 Apr 1. PMID 26893340

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c18321369-18321316 mobile_element_type = transposon:INE-1{}4877

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nazgul
    Names
    CG31235-PA
    CG31235-PB
    naz-PA
    naz-PB
    NP_001287387.1
    NP_732328.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18316075..18328942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300458.1 → NP_001287387.1  nazgul, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ46, Q9VE89
      Conserved Domains (2) summary
      cd05327
      Location:50 → 342
      retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
      COG1028
      Location:47 → 318
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

    2. NM_169806.2 → NP_732328.1  nazgul, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ46, Q9VE89
      Related
      FBpp0083009
      Conserved Domains (2) summary
      cd05327
      Location:50 → 342
      retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
      COG1028
      Location:47 → 318
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ46 Q8SZ46

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