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    Nup37 Nucleoporin 37kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup37provided by FlyBase
    Official Full Name
    Nucleoporin 37kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039301
    Locus tag
    Dmel_CG11875
    See related
    AllianceGenome:FB:FBgn0039301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11875; Dmel\CG11875; nup37
    Summary
    Predicted to be part of nuclear pore outer ring. Is expressed in organism. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NUP37 (nucleoporin 37). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup37 in Genome Data Viewer
    Location:
    96C8-96C8; 3-87 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25247658..25249100)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21073380..21074822)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bag of marbles Neighboring gene stable intronic sequence RNA CR46364 Neighboring gene Ribosomal protein S27 Neighboring gene Nucleoporin 358kD Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Lin YC, et al. Nat Neurosci, 2021 Aug. PMID 34059832, Free PMC Article
    2. Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins. Katsani KR, et al. Sci Rep, 2014 Apr 11. PMID 24722254, Free PMC Article
    3. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article
    4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
    5. Channel nuclear pore complex subunits are required for transposon silencing in Drosophila. Munafò M, et al. Elife, 2021 Apr 15. PMID 33856346, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin 37kD
    Names
    CG11875-PA
    CG11875-PB
    Nup37-PA
    Nup37-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25247658..25249100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276021.1 → NP_001262950.1  nucleoporin 37kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBU8
      Conserved Domains (3) summary
      COG2319
      Location:71 → 318
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 118
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:71 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_143103.4 → NP_651360.1  nucleoporin 37kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651360.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBU8
      Related
      FBpp0084187
      Conserved Domains (3) summary
      COG2319
      Location:71 → 318
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 118
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:71 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBU8.1 Q9VBU8

    Gene LinkOut

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