beta4GalNAcTB beta1,4-N-acetylgalactosaminyltransferase B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: beta4GalNAcTBprovided by FlyBase
Official Full Name: beta1,4-N-acetylgalactosaminyltransferase Bprovided by FlyBase
Primary source: FLYBASE:FBgn0039625
Locus tag: Dmel_CG14517
See related: AllianceGenome:FB:FBgn0039625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta4GalNacTB; beta4GalTB; betaGalNAcTB; CG14517; dbeta4GalTB; Dmel\CG14517
Summary: Enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity and beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in N-acetylglucosamine metabolic process and glycosphingolipid biosynthetic process. Located in Golgi apparatus. Is expressed in organism. Orthologous to human B4GALT5 (beta-1,4-galactosyltransferase 5) and B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29032660..29034008, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24858382..24859730, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Lumenal loop regions are insect-conserved and essential for GABPI-b4GalNAcTB interaction.
Title: "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
GABPI is required for ER export and activity of beta4GalNAcTB. [GABPI]
Title: Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

NP_651657.1

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