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    fus fusilli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fusprovided by FlyBase
    Official Full Name
    fusilliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023441
    Locus tag
    Dmel_CG8205
    See related
    AllianceGenome:FB:FBgn0023441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8205; CG8205; Dmel\CG8205; E(cact[E10])7; Fus; FUS
    Summary
    Enables mRNA binding activity. Involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including adult head; dorsal ectoderm; germ layer; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fus in Genome Data Viewer
    Location:
    52B3-52B5; 2-75 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15657318..15676669, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11544823..11564174, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-278 stem loop Neighboring gene antisense RNA:CR45143 Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene GDP-mannose pyrophosphorylase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms. Yang Y, et al. Sci Rep, 2017 Jun 20. PMID 28634384, Free PMC Article
    2. Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo. Kour S, et al. Nucleic Acids Res, 2023 Nov 10. PMID 37791873, Free PMC Article
    3. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Matsumoto T, et al. Hum Mol Genet, 2018 Apr 15. PMID 29425337
    4. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Bogaert E, et al. Cell Rep, 2018 Jul 17. PMID 30021151, Free PMC Article
    5. IN VITRO AND IN VIVO MODELS OF AMYOTROPHIC LATERAL SCLEROSIS: AN UPDATED OVERVIEW. Gois AM, et al. Brain Res Bull, 2020 Jun. PMID 32247802

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
      Title: Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
    2. C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
      Title: C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
    3. Caz is a Drosophila homologue of FUS, which is one of the genes causing amyotrophic lateral sclerosis (ALS). The novel roles for Caz and Aub demonstrated herein using the Caz-knockdown fly will contribute to a deeper understanding of the pathogenesis of ALS.
      Title: Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders.
    4. arginine residues in the C-terminal low-complexity domain are also required for maturation of FUS in cellular stress granules.
      Title: Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
    5. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration in frontotemporal dementia-amyotrophic lateral sclerosis Drosophila model.
      Title: Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
    6. Using a Drosophila model of FUS-ALS, we corroborate that induction of autophagy significantly increases survival.
      Title: Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
    7. data show that mitochondrial impairment is a critical early event in FUS proteinopathy, and provide insights into the pathogenic mechanism of FUS-induced neurodegeneration.
      Title: FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models.
    8. Our data indicate that PINK1 and Parkin play an important role in FUS-induced neurodegeneration. This study has uncovered a previously unknown link between FUS proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS proteinopathy.
      Title: PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fusilli
    Names
    CG8205-PA
    CG8205-PB
    CG8205-PC
    CG8205-PD
    CG8205-PE
    CG8205-PF
    CG8205-PG
    CG8205-PH
    enhancer of cactus[E10], number 7
    fus-PA
    fus-PB
    fus-PC
    fus-PD
    fus-PE
    fus-PF
    fus-PG
    fus-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15657318..15676669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166105.3 → NP_725479.1  fusilli, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLM9
      Related
      FBpp0086478
      Conserved Domains (4) summary
      cd12738
      Location:280 → 359
      RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12741
      Location:363 → 462
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:545 → 629
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl10012
      Location:13 → 194
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    2. NM_001169690.1 → NP_001163161.1  fusilli, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLM9, E1JH76
      Conserved Domains (4) summary
      cd12738
      Location:280 → 359
      RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12741
      Location:363 → 462
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:514 → 598
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl10012
      Location:13 → 194
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    3. NM_001259418.2 → NP_001246347.1  fusilli, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K880
      Conserved Domains (3) summary
      cd12741
      Location:29 → 128
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:180 → 264
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl17169
      Location:1 → 25
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_166106.3 → NP_725480.1  fusilli, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BJZ5
      Related
      FBpp0086481
      Conserved Domains (3) summary
      cd12741
      Location:29 → 128
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:211 → 295
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl17169
      Location:1 → 25
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_166108.3 → NP_725482.1  fusilli, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
      UniProtKB/TrEMBL
      E2QCE8
      Related
      FBpp0086476
      Conserved Domains (4) summary
      cd12738
      Location:280 → 359
      RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12741
      Location:363 → 462
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:545 → 629
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl10012
      Location:13 → 194
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    6. NM_079952.4 → NP_524691.1  fusilli, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
      UniProtKB/TrEMBL
      E2QCE8
      Related
      FBpp0086477
      Conserved Domains (4) summary
      cd12738
      Location:280 → 359
      RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12741
      Location:363 → 462
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:545 → 629
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl10012
      Location:13 → 194
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    7. NM_166107.2 → NP_725481.1  fusilli, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
      UniProtKB/TrEMBL
      E2QCE8
      Related
      FBpp0086479
      Conserved Domains (4) summary
      cd12738
      Location:280 → 359
      RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12741
      Location:363 → 462
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:545 → 629
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl10012
      Location:13 → 194
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    8. NM_166109.2 → NP_725483.1  fusilli, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BJZ5
      Related
      FBpp0086480
      Conserved Domains (3) summary
      cd12741
      Location:29 → 128
      RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:211 → 295
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
      cl17169
      Location:1 → 25
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K880 A0A0B4K880
    E1JH76 E1JH76
    E2QCE8 E2QCE8
    Q9BJZ5.1 Q9BJZ5

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