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    Serinc Serine incorporator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serincprovided by FlyBase
    Official Full Name
    Serine incorporatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028399
    Locus tag
    Dmel_CG4672
    See related
    AllianceGenome:FB:FBgn0028399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4672; Dmel\CG4672; DmSERINC; SERINC; TMS1; TMS1d
    Summary
    Predicted to be active in membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; hindgut anlage; and mesoderm. Orthologous to several human genes including SERINC1 (serine incorporator 1) and SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Serinc in Genome Data Viewer
    Location:
    72F1-72F1; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16412722..16415386)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16405822..16408486)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gag-related Neighboring gene failed axon connections Neighboring gene Glutamyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Tyrosyl-tRNA synthetase Neighboring gene doublesex cognate 73A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bipartite structural organization defines the SERINC family of HIV-1 restriction factors. Pye VE, et al. Nat Struct Mol Biol, 2020 Jan. PMID 31907454, Free PMC Article
    2. Identification of a ubiquitous family of membrane proteins and their expression in mouse brain. Grossman TR, et al. J Exp Biol, 2000 Feb. PMID 10637174
    3. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Rhiner C, et al. Dev Cell, 2010 Jun 15. PMID 20627080
    4. A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. Raymond K, et al. J Cell Sci, 2004 Jun 1. PMID 15169836
    5. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine incorporator
    Names
    CG4672-PA
    CG4672-PB
    CG4672-PC
    CG4672-PD
    CG4672-PE
    CG4672-PF
    Serinc-PA
    Serinc-PB
    Serinc-PC
    Serinc-PD
    Serinc-PE
    Serinc-PF
    TMS1
    target of methylation-induced silencing 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16412722..16415386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140636.3 → NP_648893.1  serine incorporator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U77, Q9U6P4, Q9VV58
      Related
      FBpp0075147
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 463
      Serinc; Serine incorporator (Serinc)

    2. NM_001275018.1 → NP_001261947.1  serine incorporator, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR2, Q9U6P4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 417
      Serinc; Serine incorporator (Serinc)

    3. NM_001275019.1 → NP_001261948.1  serine incorporator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI80, Q9U6P4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 460
      Serinc; Serine incorporator (Serinc)

    4. NM_001275021.1 → NP_001261950.1  serine incorporator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261950.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFH8, Q9U6P4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 459
      Serinc; Serine incorporator (Serinc)

    5. NM_001275020.1 → NP_001261949.1  serine incorporator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCT1, Q9U6P4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 456
      Serinc; Serine incorporator (Serinc)

    6. NM_001275022.1 → NP_001261951.1  serine incorporator, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFW5, Q9U6P4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 454
      Serinc; Serine incorporator (Serinc)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCT1 M9PCT1
    M9PFH8 M9PFH8
    M9PFR2 M9PFR2
    M9PFW5 M9PFW5
    M9PI80 M9PI80
    Q9U6P4 Q9U6P4
    Q9VV58 Q9VV58

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