Lsd-1 Lipid storage droplet-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lsd-1provided by FlyBase
Official Full Name: Lipid storage droplet-1provided by FlyBase
Primary source: FLYBASE:FBgn0039114
Locus tag: Dmel_CG10374
See related: AllianceGenome:FB:FBgn0039114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10374; dLSD1; Dmel\CG10374; dmPLIN1; DmPLIN1; dPlin1; lsd-1; LSD-1; lsd1; Lsd1; LSD1; Lsdp1; LSDP1; plin1; Plin1; PLIN1
Summary: Involved in several processes, including positive regulation of triglyceride catabolic process; protein localization to lipid droplet; and triglyceride mobilization. Located in lipid droplet. Part of protein-lipid complex. Is expressed in several structures, including adult head; adult heart; corpus allatum; epithelium; and fat body. Used to study obesity. Orthologous to human PLIN3 (perilipin 3) and PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95B1-95B1; 3-80 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23763857..23766662)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19589579..19592384)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of lipid storage droplet-1 delays endoreplication progression and induces cell death in Drosophila salivary gland.
Title: Depletion of lipid storage droplet-1 delays endoreplication progression and induces cell death in Drosophila salivary gland.
Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in Drosophila.
Title: Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in Drosophila.
LSD-1 functions in Drosophila thorax development by regulating JNK pathway.
Title: Dysfunction of LSD-1 induces JNK signaling pathway-dependent abnormal development of thorax and apoptosis cell death in Drosophila melanogaster.
Ova acts to link the histone h3 lysine 4 demethylase dLsd1 to HP1a for local histone modifications.
Title: Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.
We uncovered an unanticipated interplay between dLsd1 and the GATA transcription factor Serpent and we report an unexpected role for Serpent in oogenesis.
Title: A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.
Knockdown of the lipid storage droplet 1 gene in the entire Drosophila melanogaster body caused lethality, indicating that Lsd1 is an essential function for viability.
Title: Function of Lipid Storage Droplet 1 (Lsd1) in Wing Development of Drosophila melanogaster.
reductions in the expression of the Pumilio translational repressor complex enhanced phenotypes due to dLsd1 depletion in Drosophila. the PUM complex is a target of LSD1 regulation.
Title: The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop.
Lsd1 restricts the number of GSC-like cells by regulating a diverse group of genes and provide further evidence that escort cell function must be carefully controlled during development and adulthood to ensure proper germline differentiation.
Title: Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells.
SIRT1, in complex with LSD1, has a role in developmental epigenetic gene repression and regulation.
Title: A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Phosphorylation of Lsd1 promotes a 1.7-fold activation of the main fat body lipase and demonstrates the direct link between Lsd1 phosphorylation and activation of lipolysis.
Title: Function and structure of lipid storage droplet protein 1 studied in lipoprotein complexes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to lipid droplet	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
part_of protein-lipid complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lipid storage droplet-1

Names: CG10374-PA; CG10374-PB; CG10374-PC; CG10374-PD; Lsd-1-PA; Lsd-1-PB; Lsd-1-PC; Lsd-1-PD; lipid storage droplet protein 1; lipid storage droplets surface binding protein; perilipin; perilipin 1