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    Nepl4 Neprilysin-like 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl4provided by FlyBase
    Official Full Name
    Neprilysin-like 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0031805
    Locus tag
    Dmel_CG9505
    See related
    AllianceGenome:FB:FBgn0031805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9505; Dmel\CG9505
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in dorsal ectoderm anlage and ventral ectoderm anlage. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl4 in Genome Data Viewer
    Location:
    26C4-26C4; 2-19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6367882..6370190)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6367882..6370190)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44777 Neighboring gene long non-coding RNA:CR44778 Neighboring gene slow as molasses Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function and dynamics of slam in furrow formation in early Drosophila embryo. Acharya S, et al. Dev Biol, 2014 Feb 15. PMID 24368071
    2. Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Stein JA, et al. Development, 2002 Aug. PMID 12135929
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    5. Xbp1 targets canonical UPR(ER) and non-canonical pathways in separate tissues to promote longevity. Li M, et al. iScience, 2024 Jun 21. PMID 38832022, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 4
    Names
    CG9505-PA
    Nepl4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6367882..6370190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135175.3 → NP_609019.1  Neprilysin-like 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VME6
      Related
      FBpp0078883
      Conserved Domains (2) summary
      COG3590
      Location:51 → 643
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
      cl14813
      Location:59 → 649
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0S1 Q8T0S1
    Q9VME6 Q9VME6

    Gene LinkOut

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