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    Ctu2 Cytosolic thiouridylase subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctu2provided by FlyBase
    Official Full Name
    Cytosolic thiouridylase subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032793
    Locus tag
    Dmel_CG10189
    See related
    AllianceGenome:FB:FBgn0032793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10189; CTU2; Dmel\CG10189; i180; i199
    Summary
    Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Predicted to be active in cytosol. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctu2 in Genome Data Viewer
    Location:
    37E4-37E4; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19491647..19493253, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19491647..19493253, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene second mitotic wave missing Neighboring gene Topoisomerase 3alpha Neighboring gene cysts

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    2. Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP. Battersby A, et al. J Mol Biol, 2003 Jun 6. PMID 12767830
    3. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
    4. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic tRNA wobble base thiouridylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic thiouridylase subunit 2
    Names
    CG10189-PA
    CG10189-PB
    Ctu2-PA
    Ctu2-PB
    NP_001260585.1
    NP_609975.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19491647..19493253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273656.1 → NP_001260585.1  cytosolic thiouridylase subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X547, M9PDQ5, Q8MT91, Q9VIV3
      Conserved Domains (1) summary
      pfam10288
      Location:295 → 393
      CTU2; Cytoplasmic tRNA 2-thiolation protein 2

    2. NM_136131.4 → NP_609975.1  cytosolic thiouridylase subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X547, M9PDQ5, Q8MT91, Q9VIV3
      Related
      FBpp0080822
      Conserved Domains (1) summary
      pfam10288
      Location:295 → 393
      CTU2; Cytoplasmic tRNA 2-thiolation protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIV3.1 Q9VIV3

    Gene LinkOut

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