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    Cyp6w1 Cytochrome P450 6w1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6w1provided by FlyBase
    Official Full Name
    Cytochrome P450 6w1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033065
    Locus tag
    Dmel_CG8345
    See related
    AllianceGenome:FB:FBgn0033065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6w1; AntP450; CG8345; Cyp6W1; CYP6w1; CYP6W1; Dmel\CG8345
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be involved in insecticide catabolic process and response to DDT. Is expressed in embryonic Malpighian tubule segment; embryonic/larval fat body; embryonic/larval midgut; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6w1 in Genome Data Viewer
    Location:
    42A12-42A12; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6173684..6176195)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2061189..2063700)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Lysine-CTT 1-5 Neighboring gene transfer RNA:Arginine-ACG 1-4 Neighboring gene transfer RNA:Arginine-ACG 1-5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into DDT Resistance from the Drosophila melanogaster Genetic Reference Panel. Schmidt JM, et al. Genetics, 2017 Nov. PMID 28935691, Free PMC Article
    2. Xenobiotic response in Drosophila melanogaster: sex dependence of P450 and GST gene induction. Le Goff G, et al. Insect Biochem Mol Biol, 2006 Aug. PMID 16876710
    3. The biology of insecticidal activity and resistance. Perry T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21426939
    4. Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster. Wan H, et al. Pest Manag Sci, 2014 Jul. PMID 24038867
    5. Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models. Bargiela A, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31754023, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in insecticide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to DDT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6w1
    Names
    CG8345-PA
    CG8345-PB
    Cyp6w1-PA
    Cyp6w1-PB
    cytochrome P450
    NP_001286145.1
    NP_610206.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6173684..6176195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299216.1 → NP_001286145.1  cytochrome P450 6w1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9L1
      UniProtKB/TrEMBL
      A0A0B4LEU2
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 501
      p450; Cytochrome P450

    2. NM_136362.3 → NP_610206.1  cytochrome P450 6w1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9L1
      UniProtKB/TrEMBL
      A0A0B4LEU2
      Related
      FBpp0085332
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 501
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEU2 A0A0B4LEU2
    Q9V9L1.1 Q9V9L1

    Gene LinkOut

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