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    alc alicorn [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alcprovided by FlyBase
    Official Full Name
    alicornprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260972
    Locus tag
    Dmel_CG8057
    See related
    AllianceGenome:FB:FBgn0260972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8057; AMPK; AMPKbeta; betaAMPK; CG8057; Dmel\CG8057; FBgn0033383; l(2)45Ad
    Summary
    Predicted to enable protein kinase binding activity. Involved in maintenance of apical/basal cell polarity and neuron cellular homeostasis. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Orthologous to several human genes including PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alc in Genome Data Viewer
    Location:
    45A11-45A11; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9135375..9137933, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5022880..5025438, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ginseng Extract Attenuates the Injury from Ultraviolet Irradiation for Female Drosophila melanogaster through the Autophagy Signaling Pathway. She J, et al. J Med Food, 2024 Apr. PMID 38387003
    2. An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy. Poels J, et al. Autophagy, 2012 Sep. PMID 22885706, Free PMC Article
    3. A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. Pan DA, et al. Biochem J, 2002 Oct 1. PMID 12093363, Free PMC Article
    4. Metformin suppresses progression of muscle aging via activation of the AMP kinase-mediated pathways in Drosophila adults. Suzuta S, et al. Eur Rev Med Pharmacol Sci, 2022 Nov. PMID 36394755
    5. Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration. Spasić MR, et al. J Neurosci, 2008 Jun 18. PMID 18562613, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel Drosophila transgene, alicorn, encoding the single beta regulatory subunit of AMP-activated protein kinase has been isolated and characterized.
      Title: Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alicorn
    Names
    CG8057-PA
    CG8057-PB
    alc-PA
    alc-PB
    beta homologue
    beta subunit of the SNF1/AMP-activated protein kinase
    lethal (2) 45Ad

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9135375..9137933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136616.5 → NP_610460.1  alicorn, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q8, Q8IGW5
      Related
      FBpp0087705
      Conserved Domains (2) summary
      smart01010
      Location:254 → 341
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:156 → 238
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    2. NM_206061.2 → NP_995783.1  alicorn, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SG9
      Conserved Domains (2) summary
      smart01010
      Location:133 → 220
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:35 → 117
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7Q8 A1Z7Q8
    Q8IGW5 Q8IGW5
    Q95SG9 Q95SG9

    Gene LinkOut

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