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    Mic26-27 MICOS subunit 26/27 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mic26-27provided by FlyBase
    Official Full Name
    MICOS subunit 26/27provided by FlyBase
    Primary source
    FLYBASE:FBgn0038400
    Locus tag
    Dmel_CG5903
    See related
    AllianceGenome:FB:FBgn0038400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey87; anon-WO0118547.99; bs05g07.y1; CG5903; dApoO; Dmel\CG5903; MIC26-MIC27; MIC26/27
    Summary
    Predicted to be involved in cristae formation. Part of MICOS complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to several human genes including APOOL (apolipoprotein O like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mic26-27 in Genome Data Viewer
    Location:
    89B6-89B6; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16144401..16146855, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11971028..11972577, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin heavy chain-like Neighboring gene sex-specific enzyme 2 Neighboring gene Akt kinase Neighboring gene Stubble Neighboring gene uncharacterized protein Neighboring gene 48 related 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. Benincá C, et al. J Med Genet, 2021 Mar. PMID 32439808, Free PMC Article
    2. Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue. Wang LJ, et al. Biol Open, 2020 Dec 2. PMID 33268479, Free PMC Article
    3. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article
    4. Expression of Mst89B and CG31287 is Needed for Effective Sperm Storage and Egg Fertilization in Drosophila. Grewal G, et al. Cells, 2021 Feb 1. PMID 33535499, Free PMC Article
    5. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Li S, et al. Cell Rep, 2020 Aug 4. PMID 32755582, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of MICOS complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MICOS subunit 26/27
    Names
    CG5903-PA
    CG5903-PB
    CG5903-PC
    Mic26-27-PA
    Mic26-27-PB
    Mic26-27-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16144401..16146855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316507.1 → NP_001303436.1  MICOS subunit 26/27, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEY5
      Conserved Domains (1) summary
      pfam09769
      Location:42 → 180
      ApoO; Apolipoprotein O

    2. NM_142266.3 → NP_650523.1  MICOS subunit 26/27, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEY5
      Related
      FBpp0082733
      Conserved Domains (1) summary
      pfam09769
      Location:42 → 180
      ApoO; Apolipoprotein O

    3. NM_001300427.1 → NP_001287356.1  MICOS subunit 26/27, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEY5
      Conserved Domains (1) summary
      pfam09769
      Location:42 → 180
      ApoO; Apolipoprotein O
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEY5 Q9VEY5

    Gene LinkOut

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