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    Sumo Small ubiquitin like modifier [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33981, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sumoprovided by FlyBase
    Official Full Name
    Small ubiquitin like modifierprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264922
    Locus tag
    Dmel_CG4494
    See related
    AllianceGenome:FB:FBgn0264922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey240; CG4494; Dm0342; Dmel\CG4494; Dmsmt3; DmSmt3; DmSUMO-1; dsmt3; dSmt3; dSUMO; l(2)04493; l(2)SH0182; l(2)SH2 0182; smt3; Smt3; SMT3; sumo; SUMO
    Summary
    Enables protein tag activity. Involved in several processes, including dorsal appendage formation; neuron projection morphogenesis; and positive regulation of signal transduction. Located in condensed chromosome; midbody; and nucleolus. Part of outer kinetochore. Is expressed in several structures, including adult head; adult heart; embryonic cortex; germarium; and germline cell. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus 5. Orthologous to human SUMO2 (small ubiquitin like modifier 2); SUMO3 (small ubiquitin like modifier 3); and SUMO4 (small ubiquitin like modifier 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sumo in Genome Data Viewer
    Location:
    27C7-27C7; 2-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6966780..6967644, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6966780..6967644, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene septin interacting protein 2 Neighboring gene Coproporphyrinogen oxidase Neighboring gene small ribonucleoprotein particle U1 subunit 70K Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the SMT3 cDNA and gene encoding ubiquitin-like protein from Drosophila melanogaster. Huang HW, et al. Biochem Mol Biol Int, 1998 Nov. PMID 9844739
    2. Tuning the HNN experiment: generation of serine-threonine check points. Chugh J, et al. J Biomol NMR, 2008 Feb. PMID 18163215
    3. Conserved structural and dynamics features in the denatured states of drosophila SUMO, human SUMO and ubiquitin proteins: Implications to sequence-folding paradigm. Kumar D, et al. Proteins, 2009 Aug 1. PMID 19173311
    4. NMR-derived solution structure of SUMO from Drosophila melanogaster (dSmt3). Kumar D, et al. Proteins, 2009 Jun. PMID 19291740
    5. 1H, 15N, 13C resonance assignment of folded and 8 M urea-denatured state of SUMO from Drosophila melanogaster. Kumar D, et al. Biomol NMR Assign, 2008 Jun. PMID 19636913

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
      Title: Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
    2. Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster.
      Title: Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster.
    3. Structural heterogeneity in the native-state ensemble of dSmt3, the only small ubiquitin-like modifier (SUMO) in Drosophila melanogaster, was investigated and compared with its human homologue SUMO1. The native state of dSmt3 seems more flexible in comparison to SUMO1.
      Title: NMR characterization of conformational fluctuations and noncovalent interactions of SUMO protein from Drosophila melanogaster (dSmt3).
    4. the pre-mRNA destabilization caused by Dsn depletion is rescued in DIP1 or Sumo heterozygous mutants, suggesting that Dsn is a negative regulator of DIP1. Our results reveal that under normal circumstances nascent transcripts are susceptible to DIP1-mediated degradation, however intronic sequences are protected by Dsn until intron excision has taken place
      Title: SON protects nascent transcripts from unproductive degradation by counteracting DIP1.
    5. Smt3, a homolog of small ubiquitin-like modifier (sumo), is a non-canonical RIDD target in Drosophila S2 cells. Unlike other RIDD targets, the sumo transcript does not stably associate with the ER membrane
      Title: Regulation of sumo mRNA during endoplasmic reticulum stress.
    6. SUMO conjugation is required for the assembly of Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.
      Title: SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.
    7. although knockdown of the homeodomain-interacting protein kinase (Hipk) suppresses Smt3 depletion-induced activation of JNK, Hipk overexpression synergistically enhances this type of JNK activation
      Title: Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.
    8. SUMO coordinates multiple regulatory processes during oogenesis and early embryogenesis
      Title: Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation.
    9. Drosophila p53 modification by SUMO modulates its transactivation and pro-apoptotic functions
      Title: Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.
    10. Smt3 is required for the ecdysteroid synthesis pathway at the time of puparium formation.
      Title: Smt3 is required for Drosophila melanogaster metamorphosis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c6967586-6967536 mobile_element_type = transposon:mdg1{}5628

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein modification process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ubiquitin like modifier
    Names
    CG4494-PA
    CG4494-PB
    SUMO
    SUMO protein
    Sumo-PA
    Sumo-PB
    lethal (2) SH0182
    small Ubiquitin-like modifier
    smt3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6966780..6967644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058063.4 → NP_477411.1  small ubiquitin like modifier, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97102
      Related
      FBpp0078984
      Conserved Domains (1) summary
      cd16115
      Location:12 → 83
      Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

    2. NM_001316383.1 → NP_001303312.1  small ubiquitin like modifier, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97102
      Conserved Domains (1) summary
      cd16115
      Location:12 → 83
      Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97102 O97102

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