U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    wus wurst [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32683, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    wusprovided by FlyBase
    Official Full Name
    wurstprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030805
    Locus tag
    Dmel_CG9089
    See related
    AllianceGenome:FB:FBgn0030805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9089; Dmel\CG9089; l(1)G0162
    Summary
    Involved in endocytosis; extracellular matrix organization; and open tracheal system development. Located in early endosome and plasma membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Orthologous to human DNAJC22 (DnaJ heat shock protein family (Hsp40) member C22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See wus in Genome Data Viewer
    Location:
    15C4-15C4; 1-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16938244..16940873, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16832277..16834906, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44754 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 15B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    2. Time-specific regulation of airway clearance by the Drosophila J-domain transmembrane protein Wurst. Stümpges B, et al. FEBS Lett, 2011 Oct 20. PMID 21945316
    3. Expression and localization of clathrin heavy chain in Drosophila melanogaster. Wingen C, et al. Gene Expr Patterns, 2009 Oct. PMID 19577664
    4. A cell surface protein controls endocrine ring gland morphogenesis and steroid production. Pesch YY, et al. Dev Biol, 2019 Jan 1. PMID 30367846
    5. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    wurst
    Names
    CG9089-PA
    CG9089-PB
    wus-PA
    wus-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16938244..16940873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298426.1 → NP_001285355.1  wurst, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX95
      Conserved Domains (3) summary
      COG0484
      Location:327 → 385
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:331 → 385
      DnaJ; DnaJ domain
      pfam05154
      Location:47 → 97
      TM2; TM2 domain

    2. NM_132952.3 → NP_573180.1  wurst, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX95
      Related
      FBpp0074192
      Conserved Domains (3) summary
      COG0484
      Location:327 → 385
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:331 → 385
      DnaJ; DnaJ domain
      pfam05154
      Location:47 → 97
      TM2; TM2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX95 Q9VX95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools