Arl8 ADP ribosylation factor-like 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arl8provided by FlyBase
Official Full Name: ADP ribosylation factor-like 8provided by FlyBase
Primary source: FLYBASE:FBgn0037551
Locus tag: Dmel_CG7891
See related: AllianceGenome:FB:FBgn0037551
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: arl8; BcDNA:LD29185; CG7891; Dmel\CG7891; Gie; Q9VHV5
Summary: Predicted to enable guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including autophagosome-lysosome fusion; late endosome to lysosome transport; and presynapse assembly. Located in S bouton; cytoplasmic side of lysosomal membrane; and perinuclear region of cytoplasm. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to several human genes including ARL8B (ADP ribosylation factor like GTPase 8B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8126605..8129835)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3952327..3955557)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in S bouton	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasmic side of lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

Names: Arl8-PA; Arl8-PB; Arl8-PC; CG7891-PA; CG7891-PB; CG7891-PC; GTPase indispensable for equal segregation of chromosomes; novel GTPase indispensable for equal segregation of chromosomes

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