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    d4 d4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    d4provided by FlyBase
    Official Full Name
    d4provided by FlyBase
    Primary source
    FLYBASE:FBgn0033015
    Locus tag
    Dmel_CG2682
    See related
    AllianceGenome:FB:FBgn0033015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2682; D4; dd4; Dd4; Dmel\CG2682
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in nervous system development. Part of brahma complex. Is expressed in organism. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to several human genes including DPF2 (double PHD fingers 2) and DPF3 (double PHD fingers 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    41E3-41E4; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5259004..5295965)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1146509..1183470)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nipped-A Neighboring gene long non-coding RNA:CR41443 Neighboring gene super sex combs Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster. Nabirochkina E, et al. Mech Dev, 2002 Jun. PMID 12175496
    2. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Mashtalir N, et al. Cell, 2018 Nov 15. PMID 30343899, Free PMC Article
    3. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article
    4. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
    5. In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin. Tilly BC, et al. Elife, 2021 Jul 27. PMID 34313222, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 5259068-5259406 mobile_element_type = transposon:INE-1{}2485
    • Loc: 5260896-5261101 mobile_element_type = transposon:Tc1-2{}2579
    • Loc: 5262940-5264917 mobile_element_type = transposon:gypsy12{}3705
    • Loc: 5264978-5265068 mobile_element_type = transposon:1360{}3604
    • Loc: 5265687-5265985 mobile_element_type = transposon:INE-1{}3127
    • Loc: 5275704-5275779 mobile_element_type = transposon:INE-1{}3140
    • Loc: 5277195-5282574 mobile_element_type = transposon:G4{}2931
    • Loc: 5277520-5282296 mobile_element_type = transposon:G5{}3657
    • Loc: 5283685-5284144 mobile_element_type = transposon:Cr1a{}638
    • Loc: 5291385-5291442 mobile_element_type = transposon:G4{}3590
    • Loc: 5291457-5291743 mobile_element_type = transposon:INE-1{}3142

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    d4
    Names
    CG2682-PA
    CG2682-PB
    CG2682-PC
    CG2682-PD
    d4-PA
    d4-PB
    d4-PC
    d4-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5259004..5295965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165425.3 → NP_724405.2  d4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724405.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9P4
      Conserved Domains (2) summary
      cd15530
      Location:286 → 331
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15619
      Location:229 → 284
      PHD1_d4; PHD finger 1 found in d4 gene family proteins

    2. NM_136319.4 → NP_610163.1  d4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3G5
      Related
      FBpp0085418
      Conserved Domains (3) summary
      cd15530
      Location:444 → 489
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15619
      Location:387 → 442
      PHD1_d4; PHD finger 1 found in d4 gene family proteins
      pfam14051
      Location:30 → 98
      Requiem_N; N-terminal domain of DPF2/REQ

    3. NM_001273778.1 → NP_001260707.1  d4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEC3
      Conserved Domains (3) summary
      cd15530
      Location:443 → 488
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15619
      Location:386 → 441
      PHD1_d4; PHD finger 1 found in d4 gene family proteins
      pfam14051
      Location:30 → 98
      Requiem_N; N-terminal domain of DPF2/REQ

    4. NM_165424.3 → NP_724404.1  d4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6E6
      Related
      FBpp0085419
      Conserved Domains (3) summary
      cd15530
      Location:442 → 487
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15619
      Location:385 → 440
      PHD1_d4; PHD finger 1 found in d4 gene family proteins
      pfam14051
      Location:30 → 98
      Requiem_N; N-terminal domain of DPF2/REQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEC3 A0A0B4KEC3
    A1Z6E6 A1Z6E6
    Q0E9P4 Q0E9P4
    Q7K3G5 Q7K3G5

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