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    mdlc midlife crisis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42397, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mdlcprovided by FlyBase
    Official Full Name
    midlife crisisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038772
    Locus tag
    Dmel_CG4973
    See related
    AllianceGenome:FB:FBgn0038772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4973; Dmel\CG4973
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in neuron differentiation and regulation of RNA splicing. Located in nucleus. Is expressed in several structures, including imaginal disc; larval glial cell; larval neuroblast; larval neurons; and ovary. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 5. Orthologous to human RNF113A (ring finger protein 113A) and RNF113B (ring finger protein 113B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mdlc in Genome Data Viewer
    Location:
    92C4-92C4; 3-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20057748..20059291)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15883470..15885013)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regnase 1 Neighboring gene identity crisis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene I'm not dead yet 2 Neighboring gene uncharacterized protein Neighboring gene Rhodopsin 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Understanding how differentiation is maintained: lessons from the Drosophila brain. Froldi F, et al. Cell Mol Life Sci, 2016 Apr. PMID 26817462, Free PMC Article
    2. midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila. Carney TD, et al. Development, 2013 Oct. PMID 24026126, Free PMC Article
    3. Widespread adaptive evolution of Drosophila genes with sex-biased expression. Pröschel M, et al. Genetics, 2006 Oct. PMID 16951084, Free PMC Article
    4. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis. Brattig-Correia R, et al. Elife, 2024 Oct 10. PMID 39388236, Free PMC Article
    5. Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats. Jiao B, et al. Hum Mol Genet, 2021 May 29. PMID 33749734

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snoRNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    midlife crisis
    Names
    CG4973-PA
    mdlc-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20057748..20059291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142608.4 → NP_650865.1  midlife crisis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0MJ10, C0MJ16, Q9VDP8
      Related
      FBpp0083244
      Conserved Domains (3) summary
      COG5152
      Location:181 → 320
      COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]
      pfam00642
      Location:195 → 221
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:263 → 303
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDP8 Q9VDP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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