Jheh3 Juvenile hormone epoxide hydrolase 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Jheh3provided by FlyBase
Official Full Name: Juvenile hormone epoxide hydrolase 3provided by FlyBase
Primary source: FLYBASE:FBgn0034406
Locus tag: Dmel_CG15106
See related: AllianceGenome:FB:FBgn0034406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15106; Dmel\CG15106; JHEH 3; jheh3
Summary: Enables serine hydrolase activity. Predicted to be involved in epoxide metabolic process and juvenile hormone catabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18860375..18862078, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14747880..14749583, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ether hydrolase activity	IEA Inferred from Electronic Annotation more info
enables juvenile hormone epoxide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables serine hydrolase activity	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in epoxide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in juvenile hormone catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NP_611387.1

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The following sections contain reference sequences that belong to a specific genome build. Explain