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    Impbeta11 Importin beta11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Impbeta11provided by FlyBase
    Official Full Name
    Importin beta11provided by FlyBase
    Primary source
    FLYBASE:FBgn0284254
    Locus tag
    Dmel_CG33139
    See related
    AllianceGenome:FB:FBgn0284254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33139; CG8212; Dmel\CG33139; Imp beta11; imp-beta11; impbeta11; l(2)SH0971; l(2)SH2 0971; Ranbp11; RanBP11
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Is expressed in adult head; embryonic/larval hypodermal muscle cell; embryonic/larval neuromuscular junction; and organism. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Impbeta11 in Genome Data Viewer
    Location:
    52B5-52B5; 2-75 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15682719..15687415)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11570224..11574920)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43429 Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 89kDa Neighboring gene antisense RNA:CR44372 Neighboring gene Endoplasmic reticulum stress-associated serine protease Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways. Kimura M, et al. Traffic, 2014 Jul. PMID 24766099
    2. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article
    3. β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila. Beachum AN, et al. Dev Biol, 2023 Feb. PMID 36450333, Free PMC Article
    4. The Ketel gene encodes a Drosophila homologue of importin-beta. Lippai M, et al. Genetics, 2000 Dec. PMID 11102382, Free PMC Article
    5. γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor. Restrepo LJ, et al. Dev Cell, 2022 Jul 11. PMID 35654038, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin beta11
    Names
    CG33139-PA
    Impbeta11-PA
    Ranbp11
    importin-11
    importin-beta11
    lethal (2) SH0971
    ran-binding protein 11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15682719..15687415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176177.2 → NP_788357.1  importin beta11 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0Q2
      Related
      FBpp0086416
      Conserved Domains (2) summary
      smart00913
      Location:42 → 120
      IBN_N; Importin-beta N-terminal domain
      COG5657
      Location:23 → 768
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0Q2 Q7K0Q2

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