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    PIG-B Phosphatidylinositol glycan anchor biosynthesis class B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Bprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035464
    Locus tag
    Dmel_CG12006
    See related
    AllianceGenome:FB:FBgn0035464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12006; Dmel\CG12006; DmPIG-B; PIGB
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; and mesoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 80. Orthologous to human PIGB (phosphatidylinositol glycan anchor biosynthesis class B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-B in Genome Data Viewer
    Location:
    63F1-63F1; 3-9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3811263..3813958)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3811263..3813958)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43932 Neighboring gene Succinyl-coenzyme A synthetase alpha subunit 1 Neighboring gene long non-coding RNA:CR45034

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila. Yamamoto-Hino M, et al. J Cell Sci, 2020 Mar 26. PMID 32051283, Free PMC Article
    2. Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila. Yamamoto-Hino M, et al. J Cell Sci, 2018 Oct 26. PMID 30266758, Free PMC Article
    3. PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila. Yamamoto-Hino M, et al. J Cell Biol, 2024 Feb 5. PMID 38261271, Free PMC Article
    4. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Grimme SJ, et al. J Biol Chem, 2001 Jul 20. PMID 11356840
    5. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila.
      Title: PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila.
    2. Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila.
      Title: Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class B
    Names
    CG12006-PA
    CG12006-PB
    PIG-B-PA
    PIG-B-PB
    NP_647832.1
    NP_995991.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3811263..3813958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139575.3 → NP_647832.1  phosphatidylinositol glycan anchor biosynthesis class B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KV63, Q9VZM5
      Related
      FBpp0073008
      Conserved Domains (1) summary
      pfam03901
      Location:5 → 396
      Glyco_transf_22; Alg9-like mannosyltransferase family

    2. NM_206269.3 → NP_995991.1  phosphatidylinositol glycan anchor biosynthesis class B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZM5
      Conserved Domains (1) summary
      pfam03901
      Location:5 → 396
      Glyco_transf_22; Alg9-like mannosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZM5.2 Q9VZM5

    Gene LinkOut

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