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    CG10764 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10764provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034221
    Locus tag
    Dmel_CG10764
    See related
    AllianceGenome:FB:FBgn0034221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-54Ba; Dmel\CG10764; FBgn0034221; gene 2; GENE 2; SP77
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of hemocyte proliferation. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10764 in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17453399..17455729)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13340904..13343234)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene methuselah-like 4 Neighboring gene methuselah-like 3 Neighboring gene roadblock similar 54B Neighboring gene roadblock

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila. Kr P, et al. MicroPubl Biol, 2021 Feb 22. PMID 33644706, Free PMC Article
    2. Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. Bina S, et al. EMBO Rep, 2010 Mar. PMID 20168330, Free PMC Article
    3. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article
    4. Hairy transcriptional repression targets and cofactor recruitment in Drosophila. Bianchi-Frias D, et al. PLoS Biol, 2004 Jul. PMID 15252443, Free PMC Article
    5. Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development. Christesen D, et al. G3 (Bethesda), 2017 Feb 9. PMID 27974438, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hemocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10764-PA
    NP_611213.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17453399..17455729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137369.4 → NP_611213.2  uncharacterized protein Dmel_CG10764 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611213.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT2, Q8MR00
      Related
      FBpp0086075
      Conserved Domains (3) summary
      smart00020
      Location:37 → 260
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:38 → 263
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:317 → 512
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAT2 A1ZAT2
    Q8MR00 Q8MR00

    Gene LinkOut

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