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    Ns2 Nucleostemin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ns2provided by FlyBase
    Official Full Name
    Nucleostemin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034243
    Locus tag
    Dmel_CG6501
    See related
    AllianceGenome:FB:FBgn0034243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6501; Dmel\CG6501; dmNS2; Ngp; Ngp1; ns2; NS2
    Summary
    Enables GTPase activity. Involved in compound eye morphogenesis and ribosomal large subunit export from nucleus. Located in nucleolus. Colocalizes with nucleoplasm. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ns2 in Genome Data Viewer
    Location:
    54C8-54C9; 2-83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17565779..17568456, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13453284..13455961, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 54D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Plenty of SH3s Neighboring gene Ubiquinol-cytochrome c reductase 6.4 kDa subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization. Matsuo E, et al. Biosci Biotechnol Biochem, 2011. PMID 21821926
    2. Drosophila nucleostemin 2 proved essential for early eye development and cell survival. Matsuo E, et al. Biosci Biotechnol Biochem, 2010. PMID 20944412
    3. Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. Rosby R, et al. Mol Biol Cell, 2009 Oct. PMID 19710426, Free PMC Article
    4. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
    5. Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress. Wang Y, et al. Chromosoma, 2017 Jun. PMID 27150106

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleolar proteins NS1 and NS2 have similar but non-overlapping roles in the final maturation or nucleolar release of 60S ribosomal subunits.
      Title: Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress.
    2. Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization.
      Title: Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization.
    3. Drosophila nucleostemin 2 (ns2) plays a significant role in early eye development and is essential for cell survival in vivo
      Title: Drosophila nucleostemin 2 proved essential for early eye development and cell survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleostemin 2
    Names
    CG6501-PA
    Ns2-PA
    nucleostemin ortholog 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17565779..17568456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137388.4 → NP_611232.1  nucleostemin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXU4
      Related
      FBpp0086063
      Conserved Domains (3) summary
      cd01858
      Location:214 → 370
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:206 → 485
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08153
      Location:50 → 179
      NGP1NT; NGP1NT (NUC091) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXU4 Q7JXU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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