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    IFT43 Intraflagellar transport 43 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34676, updated on 9-Dec-2024

    Summary

    Official Symbol
    IFT43provided by FlyBase
    Official Full Name
    Intraflagellar transport 43provided by FlyBase
    Primary source
    FLYBASE:FBgn0032446
    Locus tag
    Dmel_CG5780
    See related
    AllianceGenome:FB:FBgn0032446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5780; Dmel\CG5780
    Summary
    Involved in positive regulation of canonical Wnt signaling pathway. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 3; retinitis pigmentosa 81; and short-rib thoracic dysplasia 18 with polydactyly. Orthologous to human IFT43 (intraflagellar transport 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See IFT43 in Genome Data Viewer
    Location:
    33F3-33F3; 2-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12693872..12694988, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12693872..12694988, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene POU domain protein 2 Neighboring gene Neprilysin-like 7 Neighboring gene Chaperonin containing TCP1 subunit 4 Neighboring gene uncharacterized protein Neighboring gene Protein interacting with C kinase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intraciliary retrograde transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intraciliary transport particle A IEA
    Inferred from Electronic Annotation
    more info
     
    part_of intraciliary transport particle A ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    intraflagellar transport 43
    Names
    CG5780-PB
    IFT43-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12693872..12694988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135737.4NP_609581.3  intraflagellar transport 43 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609581.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8Q7, Q9VK67
      Conserved Domains (1) summary
      pfam15305
      Location:101210
      IFT43; Intraflagellar transport protein 43