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    Cyt-c-p Cytochrome c proximal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyt-c-pprovided by FlyBase
    Official Full Name
    Cytochrome c proximalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284248
    Locus tag
    Dmel_CG17903
    See related
    AllianceGenome:FB:FBgn0284248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17903; CYC; CYC2; Cyct-c-p; cyt c; Cyt c; Cyt C; cyt c-p; Cyt-c; cyt-c-p; Cyt-c-P; cyt-c2; Cyt-c2; cyt.c; Cytc; CytC; CytC-2; cytC-p; Cytc-p; cytochrome c; dc4; DC4; dCyt.C-p; DMc01; Dmel\CG17903; l(2)k13905; P84029; pDMc01
    Summary
    Enables electron transfer activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Located in cytosol and mitochondrion. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; epithelial tube; ganglia; and gut section. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyt-c-p in Genome Data Viewer
    Location:
    36A11-36A12; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16719932..16722644)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16719932..16722644)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cytochrome c distal Neighboring gene Vacuolar H[+]-ATPase SFD subunit Neighboring gene mir-1006 stem loop Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure of cytochrome c from the insect Ceratitis capitata. Fernández-Sousa JM, et al. Biochim Biophys Acta, 1975 Jun 26. PMID 167835
    2. Reversible import of apocytochrome c into mitochondria. Hakvoort TB, et al. Proc Natl Acad Sci U S A, 1990 Jul. PMID 2164215, Free PMC Article
    3. Amino acid sequence requirements for the association of apocytochrome c with mitochondria. Sprinkle JR, et al. Proc Natl Acad Sci U S A, 1990 Aug. PMID 2165601, Free PMC Article
    4. Changing the invariant proline-30 of rat and Drosophila melanogaster cytochromes c to alanine or valine destabilizes the heme crevice more than the overall conformation. Koshy TI, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2174161, Free PMC Article
    5. Cytochrome c heme lyase activity of yeast mitochondria. Tong J, et al. J Biol Chem, 1998 Oct 2. PMID 9748237

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHCHD2 dynamically regulates the functions of cytochrome c in both oxidative phosphorylation and cell death in response to mitochondrial stress.
      Title: Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
    2. results reveal Blanks to be a unique component of a nuclear siRNA/dsRNA-binding complex that contributes to essential RNA silencing-related pathways in the male germ line
      Title: Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.
    3. DARK-mediated DRONC activation occurs independently of Cyt-c-p
      Title: The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxidative phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c proximal
    Names
    CG17903-PA
    CG17903-PB
    Cyt-c-p-PA
    Cyt-c-p-PB
    Cytochrome-c-proximal
    cytochrome c
    cytochrome c DC4
    cytochrome-c-p
    lethal (2) k13905

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16719932..16722644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057828.4 → NP_477176.1  cytochrome c proximal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P84029
      UniProtKB/TrEMBL
      X2J6D4
      Related
      FBpp0080446
      Conserved Domains (1) summary
      cl21467
      Location:3 → 108
      Cytochrom_C; Cytochrome c

    2. NM_001299055.1 → NP_001285984.1  cytochrome c proximal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P84029
      UniProtKB/TrEMBL
      X2J6D4
      Conserved Domains (1) summary
      cl21467
      Location:3 → 108
      Cytochrom_C; Cytochrome c
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84029.2 P84029
    X2J6D4 X2J6D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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