eEF2 eukaryotic translation elongation factor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eEF2provided by FlyBase
Official Full Name: eukaryotic translation elongation factor 2provided by FlyBase
Primary source: FLYBASE:FBgn0000559
Locus tag: Dmel_CG2238
See related: AllianceGenome:FB:FBgn0000559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.44; CG2238; chr2L:21668915..21669164; clone 1.44; Dmel\CG2238; EF-2; EF-2b; eF2; Ef2; EF2; ef2b; Ef2b; Ef2B; EF2b; EF2B
Summary: Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval mushroom body; embryonic/larval optic lobe; and imaginal disc. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21677913..21682164, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21677913..21682164, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG2238-PA; CG2238-PC; CG2238-PD; ELONGATION FACTOR 2; eEF2-PA; eEF2-PC; eEF2-PD; elongation factor 2b; eukaryotic translation elongation factor 2b

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The following sections contain reference sequences that belong to a specific genome build. Explain