crp cropped [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: crpprovided by FlyBase
Official Full Name: croppedprovided by FlyBase
Primary source: FLYBASE:FBgn0001994
Locus tag: Dmel_CG7664
See related: AllianceGenome:FB:FBgn0001994
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 35F(AT)[[17]]; AP-4; AP4; BG:DS02740.3; bHLHe63; CG7664; Crp; CRP; dAP-4; Dmel\CG7664; l(2)00232; l(2)35Fd; l(2)k00809; l(2)k03505; l(2)SH1614; l(2)SH2 1614; MS:35F.AT17
Summary: Enables myosin binding activity and sequence-specific DNA binding activity. Involved in larval somatic muscle development. Located in nucleus. Is expressed in several structures, including epithelium; eye photoreceptor cell; ganglia; imaginal disc; and salivary gland. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35F1-35F1; 2-52 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16263556..16287730, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16263556..16287730, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

find that the branching morphogenesis of terminal cells of the tracheal tubes in Drosophila requires the dMyc-dependent activation of Cropped/AP-4 protein to increase the cell growth of terminal cells
Title: Cropped, Drosophila transcription factor AP-4, controls tracheal terminal branching and cell growth.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2151 (e-PCR)
- UniSTS:50015

Dm0001 (e-PCR)
- UniSTS:11969

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c16281417-16280313 mobile_element_type = transposon:1360{}389

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in larval somatic muscle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cropped

Names: CG7664-PA; CG7664-PB; crp-PA; crp-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16263556..16287730 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299047.1 → NP_001285976.1 cropped, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285976.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V406

Conserved Domains (1) summary

pfam00010
Location:97 → 148

HLH; Helix-loop-helix DNA-binding domain
NM_057257.4 → NP_476605.1 cropped, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476605.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V406

Related

FBpp0080411

Conserved Domains (1) summary

pfam00010
Location:97 → 148

HLH; Helix-loop-helix DNA-binding domain