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    E(spl)m7-HLH Enhancer of split m7, helix-loop-helix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(spl)m7-HLHprovided by FlyBase
    Official Full Name
    Enhancer of split m7, helix-loop-helixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002633
    Locus tag
    Dmel_CG8361
    See related
    AllianceGenome:FB:FBgn0002633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHb35; CG8361; Dmel\CG8361; E(spl) m7; E(spl)-m7; E(spl)-M7; E(spl)m7; E(spl)M7; E(SPL)m7; En(spl)m7; ESPL; HLH-m7; HlHm7; HLHm7; m7; M7
    Summary
    Enables several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription corepressor binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa anlage; embryonic segment; epidermis; germ layer; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)m7-HLH in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26037038..26038019)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21862760..21863741)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split m5, helix-loop-helix Neighboring gene Enhancer of split m6, Bearded family member Neighboring gene Enhancer of split m8, helix-loop-helix Neighboring gene groucho Neighboring gene Exocyst 84

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Seidner GA, et al. Curr Biol, 2006 May 23. PMID 16713961
    2. A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Jiménez G, et al. Mol Cell Biol, 1997 Aug. PMID 9234693, Free PMC Article
    3. Reversible regulation of stem cell niche size associated with dietary control of Notch signalling. Bonfini A, et al. BMC Dev Biol, 2015 Jan 31. PMID 25637382, Free PMC Article
    4. bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability. Kiparaki M, et al. Nucleic Acids Res, 2015 Mar 11. PMID 25694512, Free PMC Article
    5. A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2. Kalive M, et al. Mol Cell Biochem, 2001 Nov. PMID 11827180

    See all (221) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split m7, helix-loop-helix
    Names
    CG8361-PA
    E(spl) region transcript 7
    E(spl) region transcript m7
    E(spl)m7
    E(spl)m7-HLH-PA
    enhancer of split m7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26037038..26038019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080505.3 → NP_536753.1  enhancer of split m7, helix-loop-helix [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13097, Q5S487, Q5S4J5, Q9VBI6
      Related
      FBpp0084334
      Conserved Domains (2) summary
      smart00511
      Location:81 → 125
      ORANGE; Orange domain
      cd00083
      Location:13 → 73
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13097.1 P13097

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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