phyl phyllopod [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: phylprovided by FlyBase
Official Full Name: phyllopodprovided by FlyBase
Primary source: FLYBASE:FBgn0013725
Locus tag: Dmel_CG10108
See related: AllianceGenome:FB:FBgn0013725
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10108; D(DmcycE[JP])2.2; Dmel\CG10108; phy1; Phyl; PHYL; SR2-3; Su(Raf)2C
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including compound eye photoreceptor fate commitment; negative regulation of signal transduction; and sensory organ precursor cell fate determination. Located in cytosol and nucleus. Part of ubiquitin ligase complex. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 51A2-51A2; 2-71 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14427336..14432337, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10314841..10319842, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified Phyllopod (Phyl) as a key regulator that drives enteroendocrine cells generation from intestinal stem cells.
Title: A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila.
Notch and Wingless signalling are regulated by phyllopod, a transcriptional target of the EGFR pathway
Title: Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway.
Negative feedback regulation of phyl controls the timing of neural precursor division.
Title: Negative-feedback regulation of proneural proteins controls the timing of neural precursor division.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R1/R6 cell fate commitment	IEP Inferred from Expression Pattern more info	PubMed
involved_in R1/R6 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell fate commitment	IEP Inferred from Expression Pattern more info	PubMed
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed