CASK CASK [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CASKprovided by FlyBase
Official Full Name: CASKprovided by FlyBase
Primary source: FLYBASE:FBgn0013759
Locus tag: Dmel_CG6703
See related: AllianceGenome:FB:FBgn0013759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: caki; Caki; CAKI; camguk; Camguk; CamguK; CamGUK; CAMGUK; cask; Cask; CaSK; CASK-beta; CG13412; CG13413; CG6703; cmg; Cmg; CMG; CMG/CASK; dCASK; DLin-2; Dmel\CG6703; RE09582p
Summary: Enables neurexin family protein binding activity. Involved in several processes, including memory; modulation of chemical synaptic transmission; and regulation of synapse organization. Located in neuromuscular junction and type I terminal bouton. Is expressed in several structures, including CNS glial cell; epithelium; ganglia; midgut primordium; and synaptic neuropil domain. Used to study autism spectrum disorder and syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93F10-93F12; 3-73 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21783400..21822674, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17609122..17648396, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery.
Title: Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery.
Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogaster.
Title: Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogaster.
Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling.
Title: Pre and postsynaptic roles for Drosophila CASK.
Full-length CASK-beta appears to have a unique role within central circuits that control motor output
Title: Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains.
Dneurexin (DNRX) is important for locomotion through a genetic interaction with the scaffold protein, CAKI/CMG, the Drosophila homolog of vertebrate CASK.
Title: Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction.
Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII.
Title: Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation.
The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function.
Title: Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release.
the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo.
Title: Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mir-4969-RA; Dmel\mir-4969-RA; CR43506-RA; Dmel\CR43506-RA

mir-4969-RB; Dmel\mir-4969-RB; CR43506-RB; Dmel\CR43506-RB

mir-999-RA; Dmel\mir-999-RA; CR43038-RA; Dmel\CR43038-RA

mir-999-RB; Dmel\mir-999-RB; CR43038-RB; Dmel\CR43038-RB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle targeting	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CASK

Names: CASK ortholog; CASK-PA; CASK-PB; CASK-PD; CASK-PE; CASK-PF; CASK-PG; CASK-PH; CASK-PI; CG6703-PA; CG6703-PB; CG6703-PD; CG6703-PE; CG6703-PF; CG6703-PG; CG6703-PH; CG6703-PI; Calcium/calmodulin-dependent protein kinase; Camguk/CASK adaptor protein; calmodulin-dependent kinase; camguk

NP_001097862.1

EC 2.7.11.1

NP_001097863.1

EC 2.7.11.1

NP_001163681.1

EC 2.7.11.1

NP_001262811.1

EC 2.7.11.1

NP_001369027.1

EC 2.7.11.1

NP_524441.2

EC 2.7.11.1

NP_732661.1

EC 2.7.11.1

NP_732662.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21783400..21822674 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170210.2 → NP_001163681.1 CASK, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163681.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIS7

Conserved Domains (7) summary

cd12081
Location:586 → 646

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

smart00072
Location:738 → 901

GuKc; Guanylate kinase homologues

smart00220
Location:12 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:493 → 573

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 308

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:728 → 901

Guanylate_kin; Guanylate kinase

pfam02828
Location:347 → 396

L27; L27 domain
NM_001275882.1 → NP_001262811.1 CASK, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262811.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH39

Conserved Domains (7) summary

cd12081
Location:586 → 646

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

smart00072
Location:720 → 883

GuKc; Guanylate kinase homologues

smart00220
Location:12 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:493 → 573

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 308

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:710 → 883

Guanylate_kin; Guanylate kinase

pfam02828
Location:347 → 396

L27; L27 domain
NM_001104393.3 → NP_001097863.1 CASK, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097863.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR72

Conserved Domains (4) summary

smart00072
Location:291 → 454

GuKc; Guanylate kinase homologues

cd00992
Location:54 → 134

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:281 → 454

Guanylate_kin; Guanylate kinase

cl17036
Location:157 → 217

SH3; Src Homology 3 domain superfamily
NM_001104392.3 → NP_001097862.1 CASK, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097862.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR71

Conserved Domains (4) summary

smart00072
Location:413 → 576

GuKc; Guanylate kinase homologues

cd00992
Location:176 → 256

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:403 → 576

Guanylate_kin; Guanylate kinase

cl17036
Location:279 → 339

SH3; Src Homology 3 domain superfamily
NM_169971.3 → NP_732662.2 CASK, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732662.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24210

Conserved Domains (4) summary

smart00072
Location:431 → 594

GuKc; Guanylate kinase homologues

cd00992
Location:176 → 256

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:421 → 594

Guanylate_kin; Guanylate kinase

cl17036
Location:279 → 339

SH3; Src Homology 3 domain superfamily
NM_079717.5 → NP_524441.2 CASK, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524441.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5X553, Q24210, Q24272, Q86P03, Q86P17, Q8SX09, Q9VD77, Q9VD78, Q9VD79

Related

FBpp0083559

Conserved Domains (7) summary

cd12081
Location:586 → 646

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

smart00072
Location:720 → 883

GuKc; Guanylate kinase homologues

smart00220
Location:12 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:493 → 573

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 308

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:710 → 883

Guanylate_kin; Guanylate kinase

pfam02828
Location:347 → 396

L27; L27 domain
NM_001382187.1 → NP_001369027.1 CASK, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EEU7

Conserved Domains (3) summary

cd00992
Location:117 → 197

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:334 → 507

Guanylate_kin; Guanylate kinase

cl17036
Location:210 → 270

SH3; Src Homology 3 domain superfamily
NM_169970.3 → NP_732661.1 CASK, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732661.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR71

Related

FBpp0083560

Conserved Domains (4) summary

smart00072
Location:413 → 576

GuKc; Guanylate kinase homologues

cd00992
Location:176 → 256

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:403 → 576

Guanylate_kin; Guanylate kinase

cl17036
Location:279 → 339

SH3; Src Homology 3 domain superfamily