ArfGAP1 ADP-ribosylation factor GTPase activating protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ArfGAP1provided by FlyBase
Official Full Name: ADP-ribosylation factor GTPase activating protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0020655
Locus tag: Dmel_CG4237
See related: AllianceGenome:FB:FBgn0020655
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AG1; ARF1-GAP; arf1GAP; CG4237; dArf1-GAP; Dmel\CG4237; gap69; Gap69c; Gap69C; GAP69C; i51
Summary: Enables GTPase activator activity. Involved in negative regulation of ARF protein signal transduction and negative regulation of endocytosis. Located in Golgi stack. Is expressed in adult head. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12415026..12417580, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12408126..12410680, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Atg2 and ArfGAP1 may have roles in modifying the eye pigmentation phenotype of AP-3 mutants in Drosophila melanogaster
Title: Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activator activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of ARF protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi stack	IGI Inferred from Genetic Interaction more info	PubMed

Names: ArfGAP1-PA; ArfGAP1-PB; CG4237-PA; CG4237-PB; GTPase-activating protein 69C

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The following sections contain reference sequences that belong to a specific genome build. Explain