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    Ac13E Adenylyl cyclase 13E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ac13Eprovided by FlyBase
    Official Full Name
    Adenylyl cyclase 13Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022710
    Locus tag
    Dmel_CG9210
    See related
    AllianceGenome:FB:FBgn0022710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 13E; ac13e; AC13E; Ac35C; CG9210; DAC9; dADCY9; Dmel\CG9210
    Summary
    Enables adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ac13E in Genome Data Viewer
    Location:
    13C7-13D2; 1-50 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15510877..15554278, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15404910..15448311, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Golgi microtubule-associated protein Neighboring gene mir-304 stem loop Neighboring gene mir-12 stem loop Neighboring gene long non-coding RNA:CR44353 Neighboring gene long non-coding RNA:CR44354 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX. Iourgenko V, et al. FEBS Lett, 1997 Aug 11. PMID 9287125
    2. A calcium-inhibited Drosophila adenylyl cyclase. Iourgenko V, et al. Biochim Biophys Acta, 2000 Feb 2. PMID 10656970
    3. A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. Yovell Y, et al. J Neurochem, 1992 Nov. PMID 1402918
    4. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
    5. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase 13E
    Names
    Ac13E-PA
    Ac13E-PB
    Ac13E-PC
    CG9210-PA
    CG9210-PB
    CG9210-PC
    adenyly cyclase 35C
    adenylyl cyclase
    adenylyl cyclase 35C
    NP_001014745.1
    NP_001259575.1
    NP_477299.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15510877..15554278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014745.2 → NP_001014745.1  adenylyl cyclase 13E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16039, Q9VXU0
      Conserved Domains (2) summary
      smart00044
      Location:289 → 505
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:348 → 522
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

    2. NM_001272646.2 → NP_001259575.1  adenylyl cyclase 13E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEP2, O16039
      Conserved Domains (2) summary
      smart00044
      Location:302 → 518
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:361 → 535
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

    3. NM_057951.3 → NP_477299.1  adenylyl cyclase 13E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16039, Q9VXU0
      Related
      FBpp0073889
      Conserved Domains (2) summary
      smart00044
      Location:289 → 505
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:348 → 522
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEP2 M9PEP2
    O16039 O16039
    Q9VXU0 Q9VXU0

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