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    Acsf3 Acyl-CoA synthetase family member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsf3provided by FlyBase
    Official Full Name
    Acyl-CoA synthetase family member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0029945
    Locus tag
    Dmel_CG18155
    See related
    AllianceGenome:FB:FBgn0029945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACSF3; CG18155; Dmel\CG18155; FBgn0029945
    Summary
    Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acsf3 in Genome Data Viewer
    Location:
    7B1-7B1; 1-20 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7329046..7331255)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7223079..7225288)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 5 Neighboring gene uncharacterized protein Neighboring gene Downstream of kinase Neighboring gene sarcoplasmic calcium-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    2. Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells. Ogura K, et al. Radiat Res, 2009 Jan. PMID 19138046
    3. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    4. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094
    5. Rosy Beginnings: Studying Peroxisomes in Drosophila. Pridie C, et al. Front Cell Dev Biol, 2020. PMID 32984330, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables malonyl-CoA synthetase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in malonate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA synthetase family member 3
    Names
    Acsf3-PB
    CG18155-PB
    NP_996360.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7329046..7331255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206637.4 → NP_996360.2  Acyl-CoA synthetase family member 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996360.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVU5
      Conserved Domains (2) summary
      COG0318
      Location:53 → 604
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      cl17068
      Location:58 → 607
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVU5 Q7KVU5

    Gene LinkOut

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