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    Hecw Hecw ubiquitin protein ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hecwprovided by FlyBase
    Official Full Name
    Hecw ubiquitin protein ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261931
    Locus tag
    Dmel_CG42797
    See related
    AllianceGenome:FB:FBgn0261931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797
    Old locus tag
    Dmel_CG3003; Dmel_CG3099
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein K63-linked ubiquitination. Is active in cytosol. Orthologous to several human genes including HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hecw in Genome Data Viewer
    Location:
    8F1-8F2; 1-29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9608946..9623243)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9502979..9517276)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Golgi-localized, gamma-adaptin ear containing, ARF binding protein Neighboring gene Lst8 Neighboring gene Lysyl-tRNA synthetase Neighboring gene Protein tyrosine phosphatase Meg2 Neighboring gene uncharacterized protein Neighboring gene nejire

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Animal HECT ubiquitin ligases: evolution and functional implications. Marín I. BMC Evol Biol, 2010 Feb 22. PMID 20175895, Free PMC Article
    2. The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress. Napoletano F, et al. Cell Rep, 2021 Sep 14. PMID 34525372
    3. Protein degradation of Lsd1 is mediated by Bre1 yet opposed by Lsd1-interacting lncRNAs during fly follicle development. Lin CT, et al. iScience, 2024 May 17. PMID 38655201, Free PMC Article
    4. Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles. Fajner V, et al. Nat Commun, 2021 Sep 16. PMID 34531401, Free PMC Article
    5. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
      Title: Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hecw ubiquitin protein ligase
    Names
    CG42797-PC
    CG42797-PD
    CG42797-PE
    CG42797-PF
    Hecw-PC
    Hecw-PD
    Hecw-PE
    Hecw-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9608946..9623243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201643.2 → NP_001188572.1  hecw ubiquitin protein ligase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS90
      Conserved Domains (3) summary
      smart00119
      Location:1089 → 1420
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1065 → 1421
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:635 → 664
      WW; WW domain

    2. NM_132346.3 → NP_572574.2  hecw ubiquitin protein ligase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8D8, Q9W326
      Conserved Domains (3) summary
      smart00119
      Location:1092 → 1423
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1068 → 1424
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:638 → 667
      WW; WW domain

    3. NM_001272456.1 → NP_001259385.1  hecw ubiquitin protein ligase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDU1, D5SHR3
      Conserved Domains (1) summary
      cd00078
      Location:76 → 432
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. NM_132347.2 → NP_572575.2  hecw ubiquitin protein ligase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572575.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDU1, Q9W325
      Conserved Domains (2) summary
      smart00119
      Location:102 → 433
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:78 → 434
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5SHR3 D5SHR3
    M9MS90 M9MS90
    Q9W325 Q9W325
    Q9W326 Q9W326

    Gene LinkOut

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