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    Pgls 6-phosphogluconolactonase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pglsprovided by FlyBase
    Official Full Name
    6-phosphogluconolactonaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030239
    Locus tag
    Dmel_CG17333
    See related
    AllianceGenome:FB:FBgn0030239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6PGL; CG17333; Dm6PGL; Dmel\CG17333; PGLS
    Summary
    Enables 6-phosphogluconolactonase activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol. Is expressed in adult head and organism. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgls in Genome Data Viewer
    Location:
    9F5-9F5; 1-33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10847438..10848534)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10741471..10742567)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small bristles Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fascetto

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Demonstration of 6-phosphogluconolactonase activity in Drosophila melanogaster using a null allele of 6-phosphogluconate dehydrogenase. Hughes MB, et al. Biochem Genet, 1978 Oct. PMID 105716
    2. A venom protein of ectoparasitoid Pachycrepoideus vindemiae, PvG6PDH, contributes to parasitism by inhibiting host glucose-6-phosphate metabolism. Yang L, et al. Insect Sci, 2022 Apr. PMID 34724344
    3. Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis. Vernì F, et al. Curr Biol, 2004 Sep 7. PMID 15341744
    4. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Bolukbasi E, et al. Open Biol, 2012 Jan. PMID 22645656, Free PMC Article
    5. Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory. de Tredern E, et al. Cell Rep, 2021 Aug 24. PMID 34433052, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 6-phosphogluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphogluconolactonase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6-phosphogluconolactonase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphogluconolactonase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphogluconolactonase
    Names
    CG17333-PA
    Pgls-PA
    NP_572656.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10847438..10848534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132428.3 → NP_572656.1  6-phosphogluconolactonase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XD9, Q9VZ64
      Related
      FBpp0073235
      Conserved Domains (1) summary
      pfam01182
      Location:14 → 228
      Glucosamine_iso; Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZ64.1 Q9VZ64

    Gene LinkOut

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