Prp16 pre-mRNA processing factor 16 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prp16provided by FlyBase
Official Full Name: pre-mRNA processing factor 16provided by FlyBase
Primary source: FLYBASE:FBgn0026713
Locus tag: Dmel_CG32604
See related: AllianceGenome:FB:FBgn0026713
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1375; cg1405; CG1405; CG32604; Dmel\CG32604; EP764; EP784; l(1)G0007; l(1)G0028; l(1)G0103; l(1)G0176; l(1)G0308; l(1)G0416; l(1)G0476; l(1)G0491; lethal (1) G0007; prp16
Summary: Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12E3-12E5; 1-48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14201362..14224732)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14095395..14118765)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1957 (e-PCR)
- UniSTS:70798

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: pre-mRNA processing factor 16

Names: CG32604-PA; CG32604-PB; Prp16-PA; Prp16-PB; lethal (1) G0007

NP_572947.1

EC 3.6.4.13

NP_727764.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14201362..14224732

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132719.3 → NP_572947.1 pre-mRNA processing factor 16, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572947.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95TT2, Q9VY54

Related

FBpp0073717

Conserved Domains (5) summary

smart00487
Location:529 → 715

DEXDc; DEAD-like helicases superfamily

smart00847
Location:932 → 1014

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:551 → 689

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00079
Location:722 → 870

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam07717
Location:1048 → 1148

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
NM_167396.2 → NP_727764.1 pre-mRNA processing factor 16, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727764.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VY50

Related

FBpp0073718

Conserved Domains (5) summary

smart00847
Location:244 → 326

HA2; Helicase associated domain (HA2) Add an annotation

COG1643
Location:1 → 444

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd00079
Location:34 → 182

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam07717
Location:360 → 460

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

pfam14265
Location:474 → 515

DUF4355; Domain of unknown function (DUF4355)