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    Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg14provided by FlyBase
    Official Full Name
    ALG14, UDP-N-acetylglucosaminyltransferase subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030645
    Locus tag
    Dmel_CG6308
    See related
    AllianceGenome:FB:FBgn0030645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ALG14; CG6308; dAlg14; Dmel\CG6308
    Summary
    Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg14 in Genome Data Viewer
    Location:
    13C4-13C4; 1-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15472164..15472859)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15366197..15366892)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip128 Neighboring gene maternal haploid Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
    2. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    3. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    4. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
      Title: Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ALG14, UDP-N-acetylglucosaminyltransferase subunit
    Names
    Alg14-PA
    B-1,4N-acglucosaminyltransferase
    CG6308-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15472164..15472859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132803.2 → NP_573031.1  ALG14, UDP-N-acetylglucosaminyltransferase subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXU7
      Related
      FBpp0073853
      Conserved Domains (1) summary
      pfam08660
      Location:9 → 190
      Alg14; Oligosaccharide biosynthesis protein Alg14 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXU7 Q9VXU7

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