kis kismet [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kisprovided by FlyBase
Official Full Name: kismetprovided by FlyBase
Primary source: FLYBASE:FBgn0266557
Locus tag: Dmel_CG3696
See related: AllianceGenome:FB:FBgn0266557
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 136/31; 2532; 5841; anon-WO0172774.164; anon-WO0257455.5; BEST:GM02209; CG18326; CG3660; CG3696; DmelPex20; Dmel\CG3696; EC2-7; EK2-4; EP(2)0474; EP474; FBtr0078144; GM02209; Kis; KIS; KIS-L; Kismet; kiss; l(2)07812; l(2)k08827; l(2)k11324; l(2)k13631; l(2)k14112; l(2)k16510; l(2)s3527; l(2)s4771; l(2)s4793; Pex20; Su(Pc)21AB
Summary: Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Involved in several processes, including determination of adult lifespan; neuron development; and segmentation. Located in nucleus. Is expressed in several structures, including epithelium; ganglia; germ layer; gut section; and imaginal disc. Used to study CHARGE syndrome; autism spectrum disorder; and congenital heart disease. Human ortholog(s) of this gene implicated in CHARGE syndrome and hypogonadotropic hypogonadism 5 with or without anosmia. Orthologous to several human genes including CHD6 (chromodomain helicase DNA binding protein 6) and CHD9 (chromodomain helicase DNA binding protein 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21B4-21B5; 2-0.5 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (210735..250823, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (210735..250823, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CHD Protein, Kismet, is Important for the Recycling of Synaptic Vesicles during Endocytosis.
Title: The CHD Protein, Kismet, is Important for the Recycling of Synaptic Vesicles during Endocytosis.
Kis is important for motor neuron synaptic morphology, the localization and clustering of postsynaptic glutamate receptors, larval motor behavior, and synaptic transmission.
Title: Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction.
KIS promotes transcription elongation and counteracts Polycomb group repression via distinct mechanisms. KIS antagonizes Polycomb group repression by facilitating ASH1-dependent H3K36 dimethylation.
Title: The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila.
the evolutionary conservation of Kismet/CHD8 function in negatively controlling hedgehog expression.
Title: A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression.
analysis of this disease model can complement and expand upon the existing studies for this disease, allowing a better understanding of the role of kismet in neural developmental, and Chd7 in CS pathogenesis
Title: Kismet/CHD7 regulates axon morphology, memory and locomotion in a Drosophila model of CHARGE syndrome.
KIS is a key transcriptional regulator of genes that function in the CRY signaling cascade, and thus it plays an important role in the synchronization of circadian rhythms with the dayrationight cycle.
Title: A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses.
promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin
Title: Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II.
facilitates an early step in transcriptional elongation by Pol II
Title: The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0566 (e-PCR)
- UniSTS:16159

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP-dependent chromatin remodeler activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kismet

Names: CG3696-PA; CG3696-PB; CG3696-PC; CG3696-PD; CG3696-PE; CG3696-PF; EP474; Kismet-L; kis-PA; kis-PB; kis-PC; kis-PD; kis-PE; kis-PF; lethal (2) k11324; lethal (2) k16510; peroxin 20

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

210735..250823 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258890.1 → NP_001245819.1 kismet, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245819.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDB7

Conserved Domains (9) summary

smart00592
Location:4304 → 4348

BRK; domain in transcription and CHROMO domain helicases

COG0553
Location:1676 → 2527

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00024
Location:1879 → 1919

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:2048 → 2197

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:2350 → 2464

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:1941 → 1996

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05285
Location:1693 → 1854

SDA1; SDA1

pfam05466
Location:1554 → 1786

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam06459
Location:3463 → 3612

RR_TM4-6; Ryanodine Receptor TM 4-6
NM_078717.3 → NP_523441.1 kismet, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523441.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NI64, Q9VPL9

Related

FBpp0077803

Conserved Domains (9) summary

PTZ00121
Location:1419 → 1923

PTZ00121; MAEBL; Provisional

PTZ00341
Location:3467 → 3692

PTZ00341; Ring-infected erythrocyte surface antigen; Provisional

PLN03142
Location:2029 → 2606

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

PRK12678
Location:1319 → 1500

PRK12678; transcription termination factor Rho; Provisional

pfam09606
Location:1056 → 1265

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18663
Location:1937 → 1995

CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins

cd18668
Location:1851 → 1918

CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins

pfam03154
Location:218 → 533

Atrophin-1; Atrophin-1 family

pfam07533
Location:4374 → 4416

BRK; BRK domain
NM_001144289.2 → NP_001137761.1 kismet, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137761.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z002

Conserved Domains (9) summary

smart00592
Location:4569 → 4613

BRK; domain in transcription and CHROMO domain helicases

COG0553
Location:1676 → 2527

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00024
Location:1879 → 1919

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:2048 → 2197

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:2350 → 2464

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:1941 → 1996

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05285
Location:1693 → 1854

SDA1; SDA1

pfam05466
Location:1554 → 1786

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam06459
Location:3728 → 3877

RR_TM4-6; Ryanodine Receptor TM 4-6
NM_001258889.1 → NP_001245818.1 kismet, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245818.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NCY5

Conserved Domains (9) summary

smart00592
Location:4395 → 4439

BRK; domain in transcription and CHROMO domain helicases

COG0553
Location:1676 → 2527

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00024
Location:1879 → 1919

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:2048 → 2197

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:2350 → 2464

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:1941 → 1996

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05285
Location:1693 → 1854

SDA1; SDA1

pfam05466
Location:1554 → 1786

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam06459
Location:3554 → 3703

RR_TM4-6; Ryanodine Receptor TM 4-6
NM_001258891.2 → NP_001245820.1 kismet, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245820.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NEL3

Conserved Domains (9) summary

smart00592
Location:4243 → 4287

BRK; domain in transcription and CHROMO domain helicases

COG0553
Location:1676 → 2527

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00024
Location:1879 → 1919

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:2048 → 2197

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:2350 → 2464

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:1941 → 1996

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05285
Location:1693 → 1854

SDA1; SDA1

pfam05466
Location:1554 → 1786

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam06459
Location:3402 → 3551

RR_TM4-6; Ryanodine Receptor TM 4-6
NM_164376.2 → NP_722617.1 kismet, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722617.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VPL6, Q9Y1L3

Related

FBpp0077804

Conserved Domains (2) summary

smart00592
Location:1203 → 1247

BRK; domain in transcription and CHROMO domain helicases

pfam06459
Location:362 → 511

RR_TM4-6; Ryanodine Receptor TM 4-6