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    Art8 Arginine methyltransferase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art8provided by FlyBase
    Official Full Name
    Arginine methyltransferase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0032329
    Locus tag
    Dmel_CG16840
    See related
    AllianceGenome:FB:FBgn0032329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16840; dART8; Dart8; DART8; Dmel\CG16840
    Summary
    Enables histone H3R2 methyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Located in nucleus. Is expressed in embryonic/larval midgut; larval muscle system; organism; and ovary. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Art8 in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11009821..11011086, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11009821..11011086, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-33A Neighboring gene Ribosomal protein L9 Neighboring gene Nucleoporin 154kD Neighboring gene antisense RNA:CR45778 Neighboring gene Deoxyuridine triphosphatase Neighboring gene SAM-motif ubiquitously expressed punctatedly localized protein Neighboring gene Accessory gland protein 32CD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster. Villar-Garea A, et al. Nucleic Acids Res, 2012 Feb. PMID 22053083, Free PMC Article
    2. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Scaramuzzino C, et al. Neuron, 2015 Jan 7. PMID 25569348, Free PMC Article
    3. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
    4. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Boulanger MC, et al. Biochem J, 2004 Apr 15. PMID 14705965, Free PMC Article
    5. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3R2 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine omega-N monomethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine methyltransferase 8
    Names
    Art8-PA
    CG16840-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11009821..11011086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135634.2 → NP_609478.1  arginine methyltransferase 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX32, Q9VKL4
      Related
      FBpp0079751
      Conserved Domains (2) summary
      COG0500
      Location:1 → 244
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam12847
      Location:40 → 147
      Methyltransf_18; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX32 Q8SX32

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