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    Oatp33Eb Organic anion transporting polypeptide 33Eb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34662, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Oatp33Ebprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 33Ebprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032435
    Locus tag
    Dmel_CG6417
    See related
    AllianceGenome:FB:FBgn0032435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6417; Dmel\CG6417; oatp 33Eb
    Summary
    Enables organic anion transmembrane transporter activity. Involved in organic anion transport and transmembrane transport. Located in lateral plasma membrane. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oatp33Eb in Genome Data Viewer
    Location:
    33E5-33E5; 2-46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12448484..12452047)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12448484..12452047)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Organic anion transporting polypeptide 33Ea Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-967 stem loop Neighboring gene bunched

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides. Groen SC, et al. Insect Biochem Mol Biol, 2017 Feb. PMID 28011348, Free PMC Article
    2. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article
    3. Resolution of the insect ouabain paradox. Torrie LS, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15347816, Free PMC Article
    4. A comprehensive review of animal models for cancer cachexia: Implications for translational research. Li L, et al. Genes Dis, 2024 Nov. PMID 39220755, Free PMC Article
    5. An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila. Santabárbara-Ruiz P, et al. Dev Cell, 2021 Oct 11. PMID 34610327

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    organic anion transporting polypeptide 33Eb
    Names
    CG6417-PA
    Oatp33Eb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12448484..12452047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135726.3 → NP_609570.1  organic anion transporting polypeptide 33Eb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK82
      Related
      FBpp0079952
      Conserved Domains (3) summary
      cd06174
      Location:50 → 267
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:430 → 483
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:23 → 619
      oat; sodium-independent organic anion transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK82 Q9VK82

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