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    CG12769 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35770, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG12769provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033252
    Locus tag
    Dmel_CG12769
    See related
    AllianceGenome:FB:FBgn0033252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12769
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12769 in Genome Data Viewer
    Location:
    44A4-44A4; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8052080..8065554, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3939585..3953059, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43724 Neighboring gene optix Neighboring gene uncharacterized protein Neighboring gene lingerer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD. Lopez-Gonzalez R, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31019093, Free PMC Article
    2. optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. Li Y, et al. Dev Biol, 2013 Sep 1. PMID 23792115, Free PMC Article
    3. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Mastushita-Sakai T, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547833, Free PMC Article
    4. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
    5. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12769-PA
    CG12769-PB
    CG12769-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8052080..8065554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165585.2 → NP_724641.1  uncharacterized protein Dmel_CG12769, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z792, F3YDG2
      Related
      FBpp0087903
      Conserved Domains (3) summary
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:651 → 678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:195 → 218
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001299252.1 → NP_001286181.1  uncharacterized protein Dmel_CG12769, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFS0, F3YDG2
      Conserved Domains (3) summary
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:662 → 689
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:195 → 218
      zf-H2C2_2; Zinc-finger double domain

    3. NM_136503.3 → NP_610347.3  uncharacterized protein Dmel_CG12769, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610347.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z791, Q8SZH3
      Related
      FBpp0087904
      Conserved Domains (3) summary
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:655 → 682
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 222
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFS0 A0A0B4LFS0
    A1Z791 A1Z791
    A1Z792 A1Z792
    Q8SZH3 Q8SZH3

    Gene LinkOut

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